ArticleAnnals of neurology2021
Characterizing the Genetic Architecture of Parkinson's Disease in Latinos.
Open access · greenAbstract read
In one paragraph
Article in Annals of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 5 pooled it
13.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 5 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Genetic variants associated with idiopathic Parkinson's disease in Latin America: A systematic review.Neurogenetics · 2025Pooled it
- Assessing the lack of diversity in genetics research across neurodegenerative diseases: A systematic review of the GWAS Catalog and literature.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Multi-ancestry genome-wide association meta-analysis of Parkinson's disease.Nature genetics · 2024Pooled it
- Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study.The Lancet. Neurology · 2023Pooled it
- Underrepresented Populations in Parkinson's Genetics Research: Current Landscape and Future Directions.Movement disorders : official journal of the Movement Disorder Society · 2022Pooled it
- Global research synergy: Advancing fundamental Parkinson's research through international collaboration.Journal of Parkinson's disease · 2026Review
- Population Attributable Risk in Alzheimer and Parkinson Diseases.Neurology. Genetics · 2026Article
- Environmental determinants of Parkinson's disease and attributable burden in Latin America.Research square · 2026Article
- Exploring MAPT-containing H1 and H2 haplotypes in Parkinson's disease across diverse populations.NPJ Parkinson's disease · 2026Article
- The Global Parkinson's Genetics Program (GP2): Advancing genetic discovery and capacity building worldwide.Journal of Parkinson's disease · 2026Review
- Parkinson Disease Pathogenic Variants: Cross-Ancestry Analysis and Microarray Data Validation.Neurology. Genetics · 2026Article
- Genome-wide association and population-tailored polygenic risk for Parkinson's disease in Taiwan.NPJ Parkinson's disease · 2026Article
- Genome-Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Bridging global diversity gaps in Parkinson disease research.Nature reviews. Neurology · 2026Review
- Population-scale burden analysis of rare damaging coding variants identifies novel risk genes for Alzheimer's disease and Parkinson's disease.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Association of LRRK2 p.A419V with Parkinson's Disease in East Asians and analysis of age at onset.NPJ Parkinson's disease · 2026Article
- EEG microstate features under visual feedback gain conditions exhibit high sensitivity in identifying early Parkinson's disease patients.Journal of neuroengineering and rehabilitation · 2026Article
- The mitogenome mutation repertoire affects progression of Parkinson's Disease.Genetics and molecular biology · 2026Article
- Exploring genetic diversity in genome-wide association studies and polygenic risk scores in the admixed Brazilian population.Genetics and molecular biology · 2026Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
39 authors at 18 institutions in 7 countries.
Douglas P LoeschInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD.ORCID 0000-0001-5716-4557
Andrea R V R HorimotoDepartment of Biostatistics, University of Washington, Seattle, WA.
Karl Heilbron23andMe, Inc., Sunnyvale, CA.
Elif I SarihanLerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH.
Miguel Inca-MartinezLerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH.
Emily MasonLerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH.
Mario Cornejo-OlivasNeurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.
Luis TorresMovement Disorders Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.
Pilar MazzettiNeurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.
Carlos CosentinoMovement Disorders Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.
Elison Sarapura-CastroNeurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.
Andrea Rivera-ValdiviaNeurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.
Angel C MedinaUniversidad Nacional del Altiplano, Puno, Peru.
Elena DieguezNeurology Institute, Universidad de la República, Montevideo, Uruguay.
Victor RaggioDepartment of Genetics, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Andres LescanoNeurology Institute, Universidad de la República, Montevideo, Uruguay.
Vitor TumasRibeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, Brazil.
Vanderci BorgesMovement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil.
Henrique B FerrazMovement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil.
Carlos R RiederDepartamento de Neurologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
Artur Schumacher-SchuhServiço de Neurologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Bruno L Santos-LobatoInstituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil.
Carlos Velez-PardoNeuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia (UdeA), Medellín, Colombia.
Marlene Jimenez-Del-RioNeuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia (UdeA), Medellín, Colombia.
Francisco LoperaNeuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia (UdeA), Medellín, Colombia.
Sonia MorenoNeuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia (UdeA), Medellín, Colombia.
Pedro Chana-CuevasCETRAM, Facultad de ciencias Medicas, Universidad de Santiago de Chile, Santiago, Chile.
William FernandezNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia.
Gonzalo ArboledaNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia.
Humberto ArboledaNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia.
Carlos E Arboleda-BustosNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia.
Dora YearoutVeterans Affairs Puget Sound Health Care System, Seattle, WA.
Cyrus P ZabetianVeterans Affairs Puget Sound Health Care System, Seattle, WA.ORCID 0000-0002-7739-4306
23andMe Research Team
Paul Cannon23andMe, Inc., Sunnyvale, CA.
Timothy A ThorntonDepartment of Biostatistics, University of Washington, Seattle, WA.
Timothy D O'ConnorInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD.
Ignacio F MataLerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH.ORCID 0000-0003-1198-0633
Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD)
Universidad de Antioquia · COUniversidad Nacional de Colombia · COUniversity of Washington · USCleveland Clinic Lerner College of Medicine · USNational University of San Marcos · PEUniversidad de la República de Uruguay · UY23andMe (United States) · USHuman Genome Sciences (United States) · USInstituto Nacional de Ciencias NeurológicasUniversidade Federal de São Paulo · BRUniversidad de Santiago de Chile · CLUniversidade de Ribeirão Preto · BRUniversidade Federal de Ciências da Saúde de Porto Alegre · BRUniversidade Federal do Pará · BRUniversidade Federal do Rio Grande do Sul · BRUniversidad Nacional del Altiplano · PEUniversidad Peruana Cayetano Heredia · PEUniversity of Puget Sound · US
Funding
Vascular Biology Training ProgramT32HL007698 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Rosemary A Kozar, Dudley K. Strickland · 1991 to 2026
$8.7MModeling the impact of Women's Specific Health Factors in PD outcomes in LatinasR01NS112499 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI FERNANDEZ MATA, IGNACIO · 2020 to 2024
$3.3MRapid Evolution of Genomic Architecture and Multi-omics TraitsR35HG010692 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI O'CONNOR, TIMOTHY DAVID · 2019 to 2023
$2.3MNHGRI NIH HHS R35 HG010692NHGRI NIH HHS R35HG010692NHLBI NIH HHS T32 HL007698NHLBI NIH HHS T32HL007698NINDS NIH HHS R01 NS112499Universidad de Antioquia 2020-31455
Abstract
objectiveThis work was undertaken in order to identify Parkinson's disease (PD) risk variants in a Latino cohort, to describe the overlap in the genetic architecture of PD in Latinos compared to European-ancestry subjects, and to increase the diversity in PD genome-wide association (GWAS) data.
methodsWe genotyped and imputed 1,497 PD cases and controls recruited from nine clinical sites across South America. We performed a GWAS using logistic mixed models; variants with a p-value <1 × 10
resultsOne locus, SNCA, achieved genome-wide significance (p-value <5 × 10
interpretationThis study demonstrated the importance of the SNCA locus for the etiology of PD in Latinos. By leveraging the demographic history of our cohort via admixture mapping, we identified two potential PD risk loci that merit further study. ANN NEUROL 2021;90:353-365.
Indexed as
AdultAgedCohort StudiesFemaleGenetic LociGenetic VariationGenome-Wide Association StudyHispanic or LatinoHumansMaleMiddle AgedParkinson DiseasePolymorphism, Single NucleotideSouth America
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.