Evidence map›Paper›PMID 34228328›Full record

SynthesisJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2022

MIBG cardiac imaging compared to ejection fraction in evaluation of cardiotoxicity: a systematic review.

Thaís Rossato Arrais, Germano Dallegrave Cavalli, Bárbara Tietbohl Dos Santos, Gabriela Bartzen Pereira, Celina Borges Migliavaca, Gabriel Blacher Grossman, Andréia Biolo

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Thaís Rossato ArraisNuclear Medicine Department, Hospital Moinhos de Vento, Rua Ramiro Barcelos, 910-201, Porto Alegre, RS, 90035-001, Brazil. thaisarrais@hotmail.com.
Germano Dallegrave CavalliCardiology Department, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Bárbara Tietbohl Dos SantosPsychiatry Department, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Gabriela Bartzen PereiraInternal Medicine Department, Santa Casa de Porto Alegre, Porto Alegre, Brazil.
Celina Borges MigliavacaPost-graduate Program in Epidemiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Gabriel Blacher GrossmanNuclear Medicine Department, Hospital Moinhos de Vento, Rua Ramiro Barcelos, 910-201, Porto Alegre, RS, 90035-001, Brazil.
Andréia BioloPost-graduate Program in Cardiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Hospital de Clínicas de Porto Alegre · BRUniversidade Federal do Rio Grande do Sul · BRHospital Moinhos de Vento · BRSanta Casa Hospital · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdvances in diagnosis and treatment of cancer has improved survival but resulted in increased cardiotoxic effects. The decrease in left ventricular ejection fraction (EF), one of the pillars of diagnosis of cardiotoxicity, seems to be a late process in the evolution of the disease, so METHODS AND

resultsA systematic search was conducted in five international databases comparing MIBG parameters with EF for evaluation of cardiotoxicity. Twelve studies were included and separated in three groups. First, studies evaluating patients with established cardiotoxicity, in which EF was reduced and MIBG parameters were abnormal. Second, studies analyzing patients during or after treatment compared to controls, with MIBG parameters significantly different between groups in most studies, even when EF remained normal. Finally, studies analyzing anthracycline (ATC) dose-related changes, with alteration in MIBG parameters occurring even when EF was preserved.

conclusionAlthough studies had high methodological variability, cardiac sympathetic innervation imaging seems to be a promising tool for assessing early cardiotoxicity. Further studies are needed to analyze its diagnostic value in this scenario.

Indexed as

3-IodobenzylguanidineCardiotoxicityAnthracyclinesHeartHumansStroke VolumeVentricular Function, Left3-IodobenzylguanidineAnthracyclinesAnthracyclinesCardiac sympathetic activityCardiotoxicityChemotherapyMIBGTrastuzumab

Identifiers

PMID34228328
OpenAlexW3178013898

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.