Evidence map›Paper›PMID 34229534›Full record

ArticleBioengineered2021

Angelica sinensis polysaccharide (ASP) attenuates diosbulbin-B (DB)-induced hepatotoxicity through activating the MEK/ERK pathway.

Chunfeng Li, Shumin Liu, Jian Zheng, Yingwei Xue

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chunfeng LiDepartment of Gastrointestinal Surgical Ward, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
Shumin LiuInstitute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Jian ZhengDepartment of Diagnostic Radiology Division, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
Yingwei XueDepartment of Gastrointestinal Surgical Ward, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.ORCID 0000-0002-8427-9736
Harbin Medical University · CNHeilongjiang University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diosbulbin-B (DB) is a promising therapeutic drug for cancer treatment; however, DB-induced hepatotoxicity seriously limits its clinical utilization. Based on this, the present study investigated whether the

Indexed as

Angelica sinensisAnimalsApoptosisAutophagyCells, CulturedCell SurvivalHepatocytesHeterocyclic Compounds, 4 or More RingsMAP Kinase Signaling SystemPlant ExtractsPolysaccharidesRatsdiosbulbin BHeterocyclic Compounds, 4 or More RingsPlant ExtractsPolysaccharidesAngelica sinensis polysaccharideapoptosisautophagydiosbulbin-BhepatotoxicityMEK/ERK pathway

Identifiers

PMID34229534
PMCPMC8806599
OpenAlexW3177587056

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.