Evidence map›Paper›PMID 34229671›Full record

ArticleLipids in health and disease2021

The effects of exercise training versus intensive insulin treatment on skeletal muscle fibre content in type 1 diabetes mellitus rodents.

David P McBey, Michelle Dotzert, C W J Melling

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David P McBeySchool of Kinesiology, Western University, Medical Sciences Building 227, London, ON, N6A 3K7, Canada.
Michelle DotzertSchool of Kinesiology, Western University, Medical Sciences Building 227, London, ON, N6A 3K7, Canada.
C W J MellingSchool of Kinesiology, Western University, Medical Sciences Building 227, London, ON, N6A 3K7, Canada. jmelling@uwo.ca.
Western University · CA

Funding

Natural Sciences and Engineering Research Council Discovery Grant RGPGP-2020-06479
6 · The paper itself

Abstract

backgroundIntensive-insulin treatment (IIT) strategy for patients with type 1 diabetes mellitus (T1DM) has been associated with sedentary behaviour and the development of insulin resistance. Exercising patients with T1DM often utilize a conventional insulin treatment (CIT) strategy leading to increased insulin sensitivity through improved intramyocellular lipid (IMCL) content. It is unclear how these exercise-related metabolic adaptations in response to exercise training relate to individual fibre-type transitions, and whether these alterations are evident between different insulin strategies (CIT vs. IIT). PURPOSE: This study examined glycogen and fat content in skeletal muscle fibres of diabetic rats following exercise-training.

methodsMale Sprague-Dawley rats were divided into four groups: Control-Sedentary, CIT- and IIT-treated diabetic sedentary, and CIT-exercised trained (aerobic/resistance; DARE). After 12 weeks, muscle-fibre lipids and glycogen were compared through immunohistochemical analysis.

resultsThe primary findings were that both IIT and DARE led to significant increases in type I fibres when compared to CIT, while DARE led to significantly increased lipid content in type I fibres compared to IIT.

conclusionsThese findings indicate that alterations in lipid content with insulin treatment and DARE are primarily evident in type I fibres, suggesting that muscle lipotoxicity in type 1 diabetes is muscle fibre-type dependant.

Indexed as

Physical Conditioning, AnimalAnimalsBlood GlucoseDiabetes Mellitus, ExperimentalFatsGlycogenInsulinMaleMuscle, SkeletalRatsRats, Sprague-DawleyBlood GlucoseFatsGlycogenInsulinExerciseInsulin treatmentIntramyocellular lipidsMuscle glycogenSkeletal muscle fibreType 1 diabetes mellitus

Identifiers

PMID34229671
PMCPMC8262066
OpenAlexW2984815277

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.