Evidence map›Paper›PMID 34229839›Full record

ReviewClinics in liver disease2021

Malnutrition and Alcohol-Associated Hepatitis.

Craig J McClain, Cristian D Rios, Sally Condon, Luis S Marsano

Open access · greenAbstract readReview
In one paragraph

Review in Clinics in liver disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Craig J McClainDivision of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, 505 South Hancock Street, Louisville, KY 40202, USA; UofL Alcohol Research Center, University of Louisville, Louisville, KY, USA; Department of Medicine, University of Louisville, Louisville, KY, USA; Hepatobiology and Toxicology Center, University of Louisville, Louisville, KY, USA; Robely Rex Veterans Affairs Medical Center, Louisville, KY 40207, USA. Electronic address: craig.mcclain@louisville.edu.
Cristian D RiosDivision of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, 505 South Hancock Street, Louisville, KY 40202, USA.
Sally CondonDivision of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, 505 South Hancock Street, Louisville, KY 40202, USA.
Luis S MarsanoDivision of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, 505 South Hancock Street, Louisville, KY 40202, USA; Department of Medicine, University of Louisville, Louisville, KY, USA.
University of Louisville · US

Funding

Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2016 to 2025
$24.1M
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9M
Next Generation Sequencing of Human Alcoholic BrainU01AA020926 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI Roy DAYNE MAYFIELD · 2011 to 2026
$6.7M
Integrated therapies for alcohol use and ALD (ITAALD) Network -UofL Clinical CenterU01AA026980 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN, Ashwani K Singal · 2018 to 2026
$2.9M
Lipid metabolites can both potentiate and treat alcoholic hepatitisU01AA026936 · NIAAA · UNIVERSITY OF LOUISVILLE · PI JOSHI-BARVE, SWATI, MCCLAIN, CRAIG J. · 2018 to 2022
$1.2M
Pilot Trial UO1 DUR-928U01AA026934 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2018 to 2022
$356k
Dietary Fat and Alcoholic Liver DiseaseI01BX002996 · VA · LOUISVILLE VA MEDICAL MEDICAL CENTER · PI MCCLAIN, CRAIG J. · 2017 to 2020
–
BLRD VA I01 BX002996NIAAA NIH HHS P50 AA024337NIAAA NIH HHS U01 AA020926NIAAA NIH HHS U01 AA026934NIAAA NIH HHS U01 AA026936NIAAA NIH HHS U01 AA026980NIGMS NIH HHS P20 GM113226
6 · The paper itself

Abstract

Malnutrition is common in alcohol-associated hepatitis (AH); almost all patients with severe AH have some component of malnutrition. The classic phenotype of malnutrition in AH is sarcopenia, but this has become more difficult to discern clinically as patients have become more obese. Patients with AH are often drinking 10 to 15 standard drinks per day. This substantial alcohol consumption becomes a major source of calories, but these are considered "empty" calories that contain little nutritional value. Malnutrition is associated with liver complications, such as hepatic encephalopathy, and worse liver outcomes. Nutrition support can improve nutrition status and reduce complications.

Indexed as

Hepatic EncephalopathyHepatitis, AlcoholicMalnutritionHumansNutritional StatusNutritional SupportAlcohol-associated hepatitis (AH)MalnutritionMicronutrientsNutritionStandard drink

Identifiers

PMID34229839
PMCPMC8672300
OpenAlexW3164809119

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.