Evidence map›Paper›PMID 34232289›Full record

ReviewEndocrinology2021

Emerging Role of Extracellular Vesicles in Prostate Cancer.

Megan Ludwig, Rhea Rajvansh, Justin M Drake

Open access · greenAbstract readReview
In one paragraph

Review in Endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Megan LudwigDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.
Rhea RajvanshDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.
Justin M DrakeDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-8329-7748
University of Minnesota · US

Funding

TRAINING GRANT IN MICROBIOLOGY/CANCER RESEARCHT32CA009138 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Scott M. Dehm · 1985 to 2026
$11.3M
Development of a novel personalized medicine platform using apheretically isolated circulating tumor cells to assess drug responsiveness in prostate cancerR41CA268344 · NCI · ASTRIN BIOSCIENCES, INC. · PI DRAKE, JUSTIN MICHAEL, PARTHASARATHY, JAYANT · 2022 to 2022
$400k
NCI NIH HHS R41 CA268344NCI NIH HHS T32 CA009138
6 · The paper itself

Abstract

Prostate cancer (PCa) is the second most common cancer among men in the United States. While the use of prostate-specific antigen has improved the ability to screen and ultimately diagnose PCa, there still remain false positives due to noncancerous conditions in the prostate gland itself and other prognostic biomarkers for PCa are needed. Contents within extracellular vesicles (EVs) have emerged as promising biomarkers that can give valuable information about disease state, and have the additional benefit of being acquired through noninvasive liquid biopsies. Meaningful communication between cancer cells and the microenvironment are carried by EVs, which impact important cellular processes in prostate cancer such as metastasis, immune regulation, and drug resistance.

Indexed as

Prostatic NeoplasmsAnimalsBiomarkers, TumorExtracellular VesiclesHumansMaleBiomarkers, TumorbiomarkersexosomesExtracellular vesiclesprostate cancer

Identifiers

PMID34232289
PMCPMC8324232
OpenAlexW3180713712

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.