ArticleJournal of thrombosis and haemostasis : JTH2021
Pathologically stiff erythrocytes impede contraction of blood clots.
Article in Journal of thrombosis and haemostasis : JTH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Mechanisms of Piezo1-Mediated Mechanotransduction in Thrombotic Diseases.International journal of molecular sciences · 2026Review
- Effect of Suturing and Adhesive Fixation on Free Gingival Graft Stability: An Ex-Vivo Porcine-Model Study.Clinical and experimental dental research · 2026Article
- Review
- Red blood cell aggregation within a blood clot causes platelet-independent clot shrinkage.Blood advances · 2025Article
- Hyperelasticity of blood clots: Bridging the gap between microscopic and continuum scales.Journal of the mechanics and physics of solids · 2024Article
- A novel technique to quantify the kinetics of blood clot contraction based on the expulsion of fluorescently labeled albumin into serum.Journal of thrombosis and haemostasis : JTH · 2024Article
- Composition of thrombi in zebrafish: similarities and distinctions with mammals.Journal of thrombosis and haemostasis : JTH · 2024Article
- Blood Clot Dynamics and Fibrinolysis Impairment in Cancer: The Role of Plasma Histones and DNA.Cancers · 2024Article
- Activation of Piezo1 channels in compressed red blood cells augments platelet-driven contraction of blood clots.Journal of thrombosis and haemostasis : JTH · 2023Article
- Why platelet mechanotransduction matters for hemostasis and thrombosis.Journal of thrombosis and haemostasis : JTH · 2023Review
- Combined computational modeling and experimental study of the biomechanical mechanisms of platelet-driven contraction of fibrin clots.Communications biology · 2023Article
- Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease.Blood · 2023Article
- Blood clot contraction: Mechanisms, pathophysiology, and disease.Research and practice in thrombosis and haemostasis · 2023Article
- Effects of diabetes mellitus complicated by admission hyperglycemia on clot histological composition and ultrastructure in patients with acute ischemic stroke.BMC neurology · 2022Article
- ADP and Thromboxane Inhibitors Both Reduce Global Contraction of Clot Length, While Thromboxane Inhibition Attenuates Internal Aggregate Contraction.TH open : companion journal to thrombosis and haemostasis · 2022Article
- Extent of intravital contraction of arterial and venous thrombi and pulmonary emboli.Blood advances · 2022Article
- Location, location, location: Fibrin, cells, and fibrinolytic factors in thrombi.Frontiers in cardiovascular medicine · 2022Review
- Physical Properties of Blood and their Relationship to Clinical Conditions.Frontiers in physiology · 2022Review
- Pathologically stiff erythrocytes impede contraction of blood clots: Reply to comment.Journal of thrombosis and haemostasis : JTH · 2021Article
- To deform or not to deform: the evolutionary basis of mammalian red blood cell deformability.Biophysical journal · 2021Article
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13 authors at 5 institutions in 3 countries.
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Abstract
backgroundBlood clot contraction, volume shrinkage of the clot, is driven by platelet contraction and accompanied by compaction of the erythrocytes and their gradual shape change from biconcave to polyhedral, with the resulting cells named polyhedrocytes.
objectivesHere, we examined the role of erythrocyte rigidity on clot contraction and erythrocyte shape transformation.
methodsWe used an optical tracking methodology that allowed us to quantify changes in contracting clot size over time. RESULTS AND
conclusionsErythrocyte rigidity has been shown to be increased in sickle cell disease (SCD), and in our experiments erythrocytes from SCD patients were 4-fold stiffer than those from healthy subjects. On average, the final extent of clot contraction was reduced by 53% in the clots from the blood of patients with SCD compared to healthy individuals, and there was significantly less polyhedrocyte formation. To test if this reduction in clot contraction was due to the increase in erythrocyte rigidity, we used stiffening of erythrocytes via chemical cross-linking (glutaraldehyde), rigidifying Wright
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.