Evidence map›Paper›PMID 34235572›Full record

ReviewHerzschrittmachertherapie & Elektrophysiologie2021

Autonomic modulation of the arrhythmogenic substrate in the evolution of atrial fibrillation and therapeutic approaches.

Stefan Ailoaei, Buelent Koektuerk, Sabine Ernst

Abstract readReview
PubMed Publisher
In one paragraph

Review in Herzschrittmachertherapie & Elektrophysiologie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Stefan AiloaeiDepartment of Cardiology, Royal Brompton Hospital, Guys' and St. Thomas's NHS Foundation Trust, Sydney Street, SW3 6NP, London, UK.
Buelent KoektuerkWitten/Herdecke University, Alfred-Herrhausen-Straße 50, 58448, Witten, Germany.
Sabine ErnstDepartment of Cardiology, Royal Brompton Hospital, Guys' and St. Thomas's NHS Foundation Trust, Sydney Street, SW3 6NP, London, UK. s.ernst@rbht.nhs.uk.
Guy's and St Thomas' NHS Foundation Trust · GBHochschule Niederrhein · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The autonomic nervous system (ANS) plays an important role in atrial arrhythmogenesis and is one of the factors responsible for the initiation and maintenance of atrial fibrillation (AF). Over the past few decades, neuromodulation has been shown to help in the management of AF. This review focuses on the correlation between AF and the ANS and how different approaches to identifying and modulating the autonomic substrate impact outcomes in AF. The authors conclude that the ANS is one of the key components in the development of AF and that modulation of autonomic nerve function may contribute to the management of AF. Therapeutic approaches such as catheter ablation of ganglionated plexi (GP), renal denervation and transcutaneous vagus nerve stimulation are viable treatment options that need further confirmation in larger randomised controlled trials. In addition, new imaging technologies were able to identify GPs accurately and reproducibly, which promises exciting prospects for the future.

Indexed as

Atrial FibrillationCatheter AblationAutonomic Nervous SystemHeart AtriaHumansAtrial arrhythmogenesisAtrial fibrillationCardiac gangliaImagingNeuromodulation

Identifiers

PMID34235572
OpenAlexW3181068703

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.