Evidence map›Paper›PMID 34236313›Full record

ArticleeLife2021

Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early

Martin H Fabry, Federica A Falconio, Fadwa Joud, Emily K Lythgoe, Benjamin Czech, Gregory J Hannon

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
8.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 52 citations in OpenAlex.

  1. Cross-species incompatibilities offer new insights into the functional consequences of satellite DNA evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Germline fate determination by a single ARGONAUTE protein inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Rapid evolution and comparative analysis of piRNA clusters inbioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Paramutation-Like Behavior of Genic piRNA-Producing Loci inInternational journal of molecular sciences · 2025
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. H3K14ac facilitates the reinstallation of constitutive heterochromatin inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. The emerging H3K9me3 chromatin landscape during zebrafish embryogenesis.bioRxiv : the preprint server for biology · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Martin H FabryCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0002-8484-4715
Federica A FalconioCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.
Fadwa JoudCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.
Emily K LythgoeCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.
Benjamin CzechCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0001-8471-0007
Gregory J HannonCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0003-4021-3898
University of Cambridge · GB

Funding

Cancer Research UK 21143Cancer Research UK A21143Cancer Research UK Core funding (A21143)Wellcome TrustWellcome Trust 110161/Z/15/Z
6 · The paper itself

Abstract

The PIWI-interacting RNA (piRNA) pathway controls transposon expression in animal germ cells, thereby ensuring genome stability over generations. In

Indexed as

AnimalsChromatinDevelopmental BiologyDNA Transposable ElementsDrosophilaDrosophila melanogasterDrosophila ProteinsEmbryonic DevelopmentEpigenomicsFemaleGene ExpressionGerm CellsHeterochromatinHistonesMaleMaternal InheritanceChromatinDNA Transposable ElementsDrosophila ProteinsHeterochromatinHistonesRNA, Small Interferingchromatinchromosomesdevelopmental biologyD. melanogasterDrosophilaembryogenesisepigeneticsgene expressionpiRNA pathwaytransposable elements

Identifiers

PMID34236313
PMCPMC8352587
OpenAlexW3178519965

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.