ArticleeLife2021
Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Proteome-wide Ubiquitinome Profiling Reveals Substrate-specific Dynamics Within the USP7 Network.Molecular & cellular proteomics : MCP · 2026Article
- PIWI-Interacting RNAs in brain health and disease: biogenesis, mechanisms, and therapeutic horizons.Psychopharmacology · 2026Review
- ARNT2 repression disrupts neuronal identity and promotes glioblastoma growth.Cell communication and signaling : CCS · 2026Article
- Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability.Nature communications · 2026Article
- Identifying Plasma Proteins Associated with Risk of Solid Cancers: A 25-Year Prospective Analysis of 4,712 Circulating Proteins in the ARIC Study.medRxiv : the preprint server for health sciences · 2026Article
- Nephron-associated Support Cell Transcriptional Plasticity Expands in Hypertension.bioRxiv : the preprint server for biology · 2026Article
- Epigenetic relay: Polycomb-directed DNA methylation in mammalian development.PLoS genetics · 2025Review
- Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals.Cancer research · 2025Article
- MAX inactivation deregulates the MYC network and induces neuroendocrine neoplasia in multiple tissues.Science advances · 2025Article
- Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1.Genes & development · 2025Article
- In vivo CRISPR screens identifyProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Development of an epigenetic clock resistant to changes in immune cell composition.Communications biology · 2024Article
- The genomic landscape of lung cancer in never-smokers from the Women's Health Initiative.JCI insight · 2024Article
- Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia.Leukemia · 2024Article
- Mutational processes of tobacco smoking and APOBEC activity generate protein-truncating mutations in cancer genomes.Science advances · 2023Article
- Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.Journal of proteome research · 2023Article
- The evolution of two transmissible cancers in Tasmanian devils.Science (New York, N.Y.) · 2023Article
- In Vivo Modeling of CLL Transformation to Richter Syndrome Reveals Convergent Evolutionary Paths and Therapeutic Vulnerabilities.Blood cancer discovery · 2023Article
- Identification of a novel target of SETD1A histone methyltransferase and the clinical significance in pancreatic cancer.Cancer science · 2023Article
- Changes of Mutations and Copy-Number and Enhanced Cell Migration during Breast Tumorigenesis.Advanced biology · 2023Article
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 1 country.
Haritha MathsyarajaBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
Jonathen CatchpoleBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
Brian FreieBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
Emily EastwoodHuman Biology and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, United States.
Ekaterina BabaevaBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
Michael GeuenichBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
Pei Feng ChengBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
Jessica AyersClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
Ming YuClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
Nan WuHuman Biology and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, United States.
Sitapriya MoorthiHuman Biology and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, United States.
Kumud R PoudelBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
Amanda KoehneComparative Pathology, Fred Hutchinson Cancer Research Center, Seattle, United States.
William GradyClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
A McGarry HoughtonHuman Biology and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, United States.
Alice H BergerHuman Biology and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, United States.
Yuzuru ShiioGreehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, United States.
David MacPhersonHuman Biology and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0003-3729-907X
Robert N EisenmanBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0002-0274-9846
Fred Hutch Cancer Center · USThe University of Texas Health Science Center at San Antonio · USUniversity of Washington · US
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1MProject 4: Risk stratification for pulmonary nodules detected by CT imaging using plasma and imaging biomarkersP50CA228944 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PHILIP D GREENBERG · 2019 to 2026
$19.6MThe MYC Transcription Factor Network and the Path to CancerR35CA231989 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI EISENMAN, ROBERT NEIL · 2018 to 2024
$6.3MUnderstanding and exploiting novel therapeutic vulnerabilities of RIT1-driven lung cancerR37CA252050 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Alice Berger · 2021 to 2026
$3.1MTranslational Science of Gastrointestinal Cancer Initiation and ProgressionR50CA233042 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Ming Yu · 2018 to 2026
$2.4MInvestigating CREBBP as a tumor suppressor in small cell lung cancerR01CA200547 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MACPHERSON, DAVID · 2017 to 2021
$2.2MHigh-Performance Compute Cluster for Comprehensive Cancer and Infectious Diseases ResearchS10OD028685 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BRADLEY, PHILIP · 2020 to 2020
$2.0MCancer Prevention and Research Institute of Texas RP160487Cancer Prevention and Research Institute of Texas RP160841Cancer Prevention and Research Institute of Texas RP190385NCI NIH HHS P30 CA054174NCI NIH HHS P50 CA228944NCI NIH HHS R01 CA200547NCI NIH HHS R35 CA231989NCI NIH HHS R37 CA252050NCI NIH HHS R50 CA233042NCI NIH HHS RO1 CA200547NCI NIH HHS U01 CA235652NIH HHS R50 CA233042NIH HHS S10 OD028685
Abstract
MGA, a transcription factor and member of the MYC network, is mutated or deleted in a broad spectrum of malignancies. As a critical test of a tumor suppressive role, we inactivated
Indexed as
Epigenetic RepressionAdenocarcinoma of LungAnimalsBasic Helix-Loop-Helix ProteinsCarcinoma, Non-Small-Cell LungCell Line, TumorDisease ProgressionFemaleHumansMaleMiceNeoplasm InvasivenessPolycomb-Group ProteinsBasic Helix-Loop-Helix ProteinsMga protein, mousePolycomb-Group Proteinscancer biologycolon organoidslung adenocarcinomaMAXMGAmousenon-canonical polycombtumor suppressor
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.