Evidence map›Paper›PMID 34238178›Full record

ReviewMicroRNA (Shariqah, United Arab Emirates)2021

MiR-147: Functions and Implications in Inflammation and Diseases.

Ling Lin, Kebin Hu

Open access · greenAbstract readReview
In one paragraph

Review in MicroRNA (Shariqah, United Arab Emirates), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ling LinNephrology Research Program, Department of Medicine, Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, United States.
Kebin HuNephrology Research Program, Department of Medicine, Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, United States.
Pennsylvania State University · US

Funding

p90 Ribosomal S6 Kinase and Chronic Kidney DiseaseR01DK102624 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HU, KEBIN · 2014 to 2018
$1.5M
NIDDK NIH HHS R01 DK102624
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs (19~25 nucleotides) that regulate gene expression at a post-transcriptional level through repression of mRNA translation or mRNA decay. MiR-147, which was initially discovered in mouse spleen and macrophages, has been shown to correlate with coronary atherogenesis and inflammatory bowel disease and modulate macrophage functions and inflammation through TLR-4. Altered miR-147 level has been shown in various human diseases, including infectious disease, cancer, cardiovascular disease, neurodegenerative disorder, etc. This review will focus on the current understanding regarding the role of miR-147 in inflammation and diseases.

Indexed as

AnimalsGene Expression RegulationHumansInflammationMacrophagesMiceMicroRNAsRNA StabilityMicroRNAsMIRN147 microRNA, humancancercardiovascular diseaseinfectious diseaseinflammation.miR-147neurodegenerative disorder

Identifiers

PMID34238178
PMCPMC8714690
OpenAlexW3178848562

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.