Evidence map›Paper›PMID 34239277›Full record

SynthesisWorld journal of gastroenterology2021

Disorders of the brain-gut interaction and eating disorders.

Mihaela Fadgyas Stanculete, Giuseppe Chiarioni, Dan Lucian Dumitrascu, Dinu Iuliu Dumitrascu, Stefan-Lucian Popa

Abstract readSystematic Review
In one paragraph

Synthesis in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Review
  4. Article
  5. Management of Constipation in Eating Disorders-A Scoping Review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Ten controversies in gastroparesis and a look to the future.Neurogastroenterology and motility · 2023
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mihaela Fadgyas StanculeteDepartment of Neurosciences, Discipline of Psychiatry and Pediatric Psychiatry, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca RO 400174, Romania.
Giuseppe ChiarioniDivision of Gastroenterology of the University of Verona, AOUI Verona, Verona 37134, Italy. chiarioni@alice.it.
Dan Lucian DumitrascuDepartment of The Second Medical, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca RO 400174, Cluj, Romania.
Dinu Iuliu DumitrascuDepartment of Anatomy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca RO 400174, Cluj, Romania.
Stefan-Lucian PopaDepartment of The Second Medical, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca RO 400174, Cluj, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEating disorders (ED) involve both the nervous system and the gastrointestinal tract. A similar double involvement is also found in disorders of the brain-gut interaction (DGBI) and symptoms are sometimes similar.

aimTo find out where there is an association and a cause-effect relationship, we looked for the comorbidity of DGBI and ED.

methodsA systematic review was undertaken. A literature search was performed. Inclusion criteria for the articles retained for analysis were: Observational cohort population-based or hospital-based and case-control studies, examining the relationship between DGBI and ED. Exclusion criteria were: Studies written in other languages than English, abstracts, conference presentations, letters to the Editor and editorials. Selected papers by two independent investigators were critically evaluated and included in this review.

resultsWe found 29 articles analyzing the relation between DGBI and ED comprising 13 articles on gastroparesis, 5 articles on functional dyspepsia, 7 articles about functional constipation and 4 articles on irritable bowel syndrome.

conclusionThere is no evidence for a cause-effect relationship between DGBI and ED. Their common symptomatology requires correct identification and a tailored therapy of each disorder.

Indexed as

DyspepsiaFeeding and Eating DisordersIrritable Bowel SyndromeBrainConstipationHumansConstipationDyspepsiaEating disordersGastroparesisIrritable bowel syndrome, Anorexia

Identifiers

PMID34239277
PMCPMC8240049

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.