ArticlePloS one2021
Association between smoking history and optical coherence tomography angiography findings in diabetic patients without diabetic retinopathy.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Time above range and no coefficient of variation is associated with diabetic retinopathy in individuals with type 1 diabetes and glycated hemoglobin within target.Acta diabetologica · 2025Article
- Fundus blood flow density changes in the smoking population by artificial intelligence-based optical coherence tomography angiography.International journal of ophthalmology · 2025Article
- The association of cigarette smoking with the development and progression of diabetic retinopathy: based on cross-sectional survey and mendelian randomization.Journal of translational medicine · 2024Article
- Impairment of Neurovascular Function in Intermediate Age-Related Macular Degeneration.Translational vision science & technology · 2024Article
- What else can we do to prevent diabetic retinopathy?Diabetologia · 2023Article
- Racial differences in quantitative optical coherence tomography angiography findings between older non-diabetics with co-morbidities.PloS one · 2023Article
- Comment on Retinal findings of COVID-19 patients using ocular coherence tomography angiography two to three months after infection: Ocular appearance recovered COVID-19 patient.Photodiagnosis and photodynamic therapy · 2022Article
- Reduced Vessel Density in the Mid-Periphery and Peripapillary Area of the Superficial Capillary Plexus in Non-Proliferative Diabetic Retinopathy.Journal of clinical medicine · 2022Article
- Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus-Report 2: Diabetic Kidney Disease.Journal of clinical medicine · 2021Article
- Risk-Profile and Feature Selection Comparison in Diabetic Retinopathy.Journal of personalized medicine · 2021Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
purposeTo investigate any associations between cigarette smoking and retinal microvascular changes in diabetic patients without visible retinopathy.
designRetrospective, cross-sectional study.
participants1099 eyes from 1099 diabetic patients with no clinical evidence of diabetic retinopathy (DR) were included in this study.
methodsDiabetic patients underwent optical coherence tomography angiography (OCTA) scanning at Zuckerberg San Francisco General Hospital and Trauma Center between April 2018 and September 2019. Patient demographic and clinical information was collected. Standard bivariate statistics and multivariate linear regression were performed.
main outcome measuresOCTA parameters included metrics related to the foveal avascular zone (FAZ; area, perimeter, circularity), perfusion density (PD; full, center, inner), and vessel length density (VLD; full, center, inner).
resultsThe study population included 750 non-smokers and 349 smokers. FAZ perimeter was the only OCTA parameter that was significantly different between the two groups on uncontrolled analysis (P = 0.033). Multivariate regression analyses revealed significant associations between lower VLD full (β = -0.31, P = 0.048), lower VLD inner (β = -0.35, P = 0.046) and a history of smoking. No significant associations between cigarette smoking and either FAZ or PD were detected.
conclusionsOur results suggest that smoking is likely associated with deleterious changes in the retinal microvasculature of patients with a history of diabetes and no visible DR. Based on these findings, diabetic patients with a history of smoking may benefit from higher prioritization in terms of ophthalmic screening.
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