Evidence map›Paper›PMID 34244155›Full record

Trial reportCancer prevention research (Philadelphia, Pa.)2021

Change in Blood and Benign Breast Biomarkers in Women Undergoing a Weight-Loss Intervention Randomized to High-Dose ω-3 Fatty Acids versus Placebo.

Carol J Fabian, Christie A Befort, Teresa A Phillips, Jennifer L Nydegger, Amy L Kreutzjans, Kandy R Powers, Trina Metheny, Jennifer R Klemp, Susan E Carlson, Debra K Sullivan and 5 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cancer prevention research (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02101970 (Randomized Pilot Trial of Omega-3 Fatty Acids or Placebo in Peri- or Post-Menopausal Women at High Risk for Breast Cancer Undergoing a Weight Loss Intervention), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02101970 nacompletednot on this map

Randomized Pilot Trial of Omega-3 Fatty Acids or Placebo in Peri- or Post-Menopausal Women at High Risk for Breast Cancer Undergoing a Weight Loss Intervention

TypeinterventionalSponsorCarol Fabian, MDRan2014 to 2018Enrolled46ConditionsBreast CancerArmsOmega-3 Fatty Acids, Placebo Capsule, Diet and Exercise
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Carol J FabianDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas. cfabian@kumc.edu.ORCID 0000-0002-8855-4133
Christie A BefortDepartment of Population Health, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0003-4290-9979
Teresa A PhillipsDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Jennifer L NydeggerDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Amy L KreutzjansDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Kandy R PowersDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Trina MethenyDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Jennifer R KlempDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Susan E CarlsonDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, Kansas.
Debra K SullivanDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, Kansas.
Carola M ZallesDepartment of Pathology, Boca Raton Regional Hospital, Boca Raton, Florida.
Erin D GilesDepartment of Nutrition, Agriculture and Life Sciences, Texas A&M University, College Station, Texas.ORCID 0000-0002-8677-2831
Stephen D HurstingDepartment of Nutrition and Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Jinxiang HuDepartment of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas.
Bruce F KimlerDepartment of Radiation Oncology, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0001-7021-6964
University of Kansas Medical Center · USBoca Raton Regional Hospital · USTexas A&M University · USUniversity of North Carolina at Chapel Hill · US

Funding

Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
NCI NIH HHS P30 CA168524NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

The inflammation-resolving and insulin-sensitizing properties of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids have potential to augment effects of weight loss on breast cancer risk. In a feasibility study, 46 peri/postmenopausal women at increased risk for breast cancer with a body mass index (BMI) of 28 kg/m

Indexed as

Weight Reduction ProgramsAdultAgedBehavior TherapyBiomarkers, TumorBreastBreast NeoplasmsCaloric RestrictionCytodiagnosisDietary SupplementsExerciseFatty Acids, Omega-3Feasibility StudiesFemaleHumansMiddle AgedBiomarkers, TumorFatty Acids, Omega-3Placebos

Identifiers

PMID34244155
PMCPMC8416797
OpenAlexW3180203856

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.