Evidence map›Paper›PMID 34250048›Full record

ArticleFrontiers in cardiovascular medicine2021

Effects of Altering Mitochondrial Antioxidant Capacity on Molecular and Phenotypic Drivers of Fibrocalcific Aortic Valve Stenosis.

Carolyn M Roos, Bin Zhang, Michael A Hagler, Grace C Verzosa, Runqing Huang, Elise A Oehler, Arman Arghami, Jordan D Miller

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Carolyn M RoosDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Bin ZhangDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Michael A HaglerDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Grace C VerzosaDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Runqing HuangDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Elise A OehlerDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Arman ArghamiDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Jordan D MillerDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Mayo Clinic in Arizona · US

Funding

Role of SIRT6 in calcific aortic valve diseaseR01HL111121 · NHLBI · MAYO CLINIC ROCHESTER · PI MILLER, JORDAN D · 2013 to 2017
$2.0M
Role of senescent cells in the pathogenesis of Marfan-associated cardiovascular diseaseR01HL141819 · NHLBI · MAYO CLINIC ROCHESTER · PI MILLER, JORDAN D · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL111121NHLBI NIH HHS R01 HL141819
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

calcificationfibrocalcific aortic valve diseasemitochondriaMnSODoxidative stress

Identifiers

PMID34250048
PMCPMC8263922
OpenAlexW3174934303

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.