Evidence map›Paper›PMID 34252326›Full record

ArticlePhysiological genomics2021

Chronic binge alcohol and ovariectomy dysregulate omental adipose tissue metaboproteome in simian immunodeficiency virus-infected female macaques.

Jonquil M Poret, Jessie J Guidry, Liz Simon, Patricia E Molina

Open access · greenAbstract readComparative Study
In one paragraph

Article in Physiological genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jonquil M PoretDepartment of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.ORCID 0000-0002-7103-9514
Jessie J GuidryDepartment of Biochemistry and The Proteomic Core Facility, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
Liz SimonDepartment of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.ORCID 0000-0003-4149-3406
Patricia E MolinaDepartment of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
Louisiana State University Health Sciences Center New Orleans · US

Funding

Translational Research/Education ComponentP60AA009803 · NIAAA · LSU HEALTH SCIENCES CENTER · PI PATRICIA E. MOLINA · 2004 to 2026
$42.6M
BIOMEDICAL ALCOHOL RESEARCH TRAINING PROGRAMT32AA007577 · NIAAA · LSU HEALTH SCIENCES CENTER · PI PATRICIA E. MOLINA · 1999 to 2026
$9.6M
Chronic binge alcohol in SIV infection: impact of adipose tissue stiffness on metabolic dysfunctionF31AA028459 · NIAAA · LSU HEALTH SCIENCES CENTER · PI PORET, JONQUIL M · 2020 to 2022
$114k
NIAAA NIH HHS F31 AA028459NIAAA NIH HHS P60 AA009803NIAAA NIH HHS T32 AA007577
6 · The paper itself

Abstract

Effective antiretroviral therapy (ART) has significantly reduced mortality of people living with HIV (PLWH), and the prevalence of at-risk alcohol use is higher among PLWH. Increased survival and aging of PLWH is associated with increased prevalence of metabolic comorbidities especially among menopausal women, and adipose tissue metabolic dysregulation may be a significant contributing factor. We examined the differential effects of chronic binge alcohol (CBA) administration and ovariectomy (OVX) on the omental adipose tissue (OmAT) proteome in a subset of simian immunodeficiency virus (SIV)-infected macaques of a longitudinal parent study. Quantitative discovery-based proteomics identified 1,429 differentially expressed proteins. Ingenuity Pathway Analysis (IPA) was used to calculate

Indexed as

AlcoholismAnimalsBinge DrinkingBody CompositionFemaleIntra-Abdominal FatMacaca mulattaOvariectomyProteinsSimian Acquired Immunodeficiency SyndromeProteinsadiposealcoholovariectomyproteomicsSIV

Identifiers

PMID34252326
PMCPMC8409904
OpenAlexW3181713516

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.