ArticlePhysics and imaging in radiation oncology2021
Cone beam computed tomography based image guidance and quality assessment of prostate cancer for magnetic resonance imaging-only radiotherapy in the pelvis.
Article in Physics and imaging in radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Synthetic CT imaging for pelvic and abdominal MR-only radiotherapy: Clinical validation on a 1.5T MR-Linac.Journal of applied clinical medical physics · 2026Article
- Cone beam computed tomography image guidance within a magnetic resonance imaging-only planning workflow.Physics and imaging in radiation oncology · 2023Article
- Evaluation of MRI-only based online adaptive radiotherapy of abdominal region on MR-linac.Journal of applied clinical medical physics · 2023Article
- Head and neck cancer patient positioning using synthetic CT data in MRI-only radiation therapy.Journal of applied clinical medical physics · 2022Article
- Patient position verification in magnetic-resonance imaging only radiotherapy of anal and rectal cancers.Physics and imaging in radiation oncology · 2021Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
background and purposeRadiotherapy (RT) based on magentic resonance imaging (MRI) only is currently used clinically in the pelvis. A synthetic computed tomography (sCT) is needed for dose planning. Here, we investigate the accuracy of cone beam CT (CBCT) based MRI-only image guided RT (IGRT) and sCT image quality. MATERIALS AND
methodsCT, MRI and CBCT scans of ten prostate cancer patients were included. The MRI was converted to a sCT using a multi-atlas approach. The sCT, CT and MR images were auto-matched with the CBCT on the bony anatomy. Paired sCT-CT and sCT-CBCT data were created. CT numbers were converted to relative electron (RED) and mass densities (DES) using a standard calibration curve for the CT and sCT. For the CBCT RED/DES conversion, a phantom and paired CT-CBCT population based calibration curve was used. For the latter, the CBCT numbers were averaged in 100 HU bins and the known RED/DES of the CT were assigned. The paired sCT-CT and sCT-CBCT data were averaged in bins of 10 HU or 0.01 RED/DES. The median absolute error (MeAE) between the sCT-CT and sCT-CBCT bins was calculated. Wilcoxon rank-sum tests were carried out for the IGRT and MeAE study.
resultsThe mean sCT or MR IGRT difference from CT was ≤ 2 mm but significant differences were observed. A CBCT HU or phantom-based RED/DES MeAE did not estimate the sCT quality similar to a CT based MeAE but the CBCT population-based RED/DES MeAE did.
conclusionsMRI-only CBCT-based IGRT seems feasible but caution is advised. A MeAE around 0.1 DES could call for sCT quality inspection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.