Evidence map›Paper›PMID 34259093›Full record

ArticleDrug delivery2021

Synergic fabrication of pembrolizumab loaded doxorubicin incorporating microbubbles delivery for ultrasound contrast agents mediated anti-proliferation and apoptosis.

Huilin Liu, Xing Li, Zihe Chen, Lianjie Bai, Ying Wang, Weiyang Lv

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Huilin LiuDepartment of Ultrasound, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar City, PR China.
Xing LiDepartment of Ultrasound, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar City, PR China.
Zihe ChenSchool of Medical Technology, Qiqihar Medical University, Qiqihar City, PR China.
Lianjie BaiDepartment of Ultrasound, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar City, PR China.
Ying WangDepartment of Ultrasound, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar City, PR China.
Weiyang LvDepartment of Ultrasound, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar City, PR China.
Qiqihar Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated pembrolizumab-conjugated, doxorubicin (DOX)-loaded microbubbles (PDMs) in combination with ultrasound (US) as molecular imaging agents for early diagnosis of B cell lymphomas, and as a targeted drug delivery system. Pembrolizumab, a monoclonal CD20 antibody, was attached to the surfaces of DOX-loaded microbubbles. PDM binding to B cell lymphoma cells was assessed using immunofluorescence. The cytotoxic effects of PDMs in combination with ultrasound (PDMs + US) were evaluated

Indexed as

MicrobubblesAnimalsAntibodies, Monoclonal, HumanizedAntineoplastic AgentsApoptosisCell Line, TumorCell SurvivalChemistry, PharmaceuticalContrast MediaDoxorubicinDrug CarriersDrug CombinationsDrug LiberationHumansLymphoma, B-CellMiceAntibodies, Monoclonal, HumanizedAntineoplastic AgentsContrast MediaDoxorubicinDrug CarriersDrug CombinationspembrolizumabPolylactic Acid-Polyglycolic Acid CopolymerB cell lymphomamicrobubblePembrolizumabtheranosticsultrasound

Identifiers

PMID34259093
PMCPMC8281080
OpenAlexW3182864396

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.