Evidence map›Paper›PMID 34259613›Full record

ReviewHuman vaccines & immunotherapeutics2022

Emerging antibody-based products for infectious diseases: Planning for metric ton manufacturing.

Kevin J Whaley, Larry Zeitlin

Open access · bronzeAbstract readReview
In one paragraph

Review in Human vaccines & immunotherapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Aerosolized mRNA monoclonal antibodies: A new frontier in passive immunization for neonatal foals.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  7. Monoclonal Antibody Therapies for Infectious Diseases.Current topics in microbiology and immunology · 2025
    Review
  8. Trafficking and localization of Golgi-residentFrontiers in plant science · 2025
    Review
  9. Article
  10. Article
  11. Monoclonal Antibody Generation Using Single B Cell Screening for Treating Infectious Diseases.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Special focus issue: passive immunization.Human vaccines & immunotherapeutics · 2022
    Article
  17. Article
  18. Effects of Low Dose Neutron-Gamma Field on Cell Cycle and Damage of Human Lymphocytes.Dose-response : a publication of International Hormesis Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Kevin J WhaleyMapp Biopharmaceutical, San Diego, CA, USA.
Larry ZeitlinMapp Biopharmaceutical, San Diego, CA, USA.
University of Zakho · IQ

Funding

Research Project 3: siRNA Therapy and Small Molecule Combination Treatment for FilovirusesU19AI142785 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GEISBERT, THOMAS WILLIAM · 2019 to 2023
$35.5M
Project 3 - USUHSU19AI142764 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI BRODER, CHRISTOPHER C · 2019 to 2023
$24.6M
Prometheus: A Platform for Rapid Development of Human Antibody-based Therapeutics and Prophylactics against Emerging Viral ThreatsU19AI142777 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI CHANDRAN, KARTIK · 2019 to 2023
$21.9M
NIAID NIH HHS U19 AI142764NIAID NIH HHS U19 AI142777NIAID NIH HHS U19 AI142785
6 · The paper itself

Abstract

This review focuses on the emerging monoclonal antibody market for infectious diseases and the metric ton scale manufacturing requirements to meet global demand. Increasing access to existing antibody-based products coupled with the unmet need in infectious disease will likely exceed the current existing global manufacturing capacity. Further, the large numbers of individuals infected during epidemics such as the ongoing COVID-19 pandemic emphasizes the need to plan for metric ton manufacturing of monoclonal antibodies by expanding infrastructure and exploring alternative production systems.

Indexed as

Communicable DiseasesCOVID-19Antibodies, MonoclonalCommerceHumansPandemicsAntibodies, MonoclonalmanufacturingMonoclonalpassive immunizationscale

Identifiers

PMID34259613
PMCPMC9103258
OpenAlexW3178182054

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.