Evidence map›Paper›PMID 34260401›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Regulation and drug modulation of a voltage-gated sodium channel: Pivotal role of the S4-S5 linker in activation and slow inactivation.

Jinglei Xiao, Vasyl Bondarenko, Yali Wang, Antonio Suma, Marta Wells, Qiang Chen, Tommy Tillman, Yan Luo, Buwei Yu, William P Dailey and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Hyperpolarization Modulation of the T-Type hCaAngewandte Chemie (International ed. in English) · 2025
    Article
  2. Article
  3. Eugenol and lidocaine inhibit voltage-gated NaFrontiers in pharmacology · 2024
    Article
  4. Blockers of Skeletal Muscle NaInternational journal of molecular sciences · 2023
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jinglei XiaoDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0002-2365-5363
Vasyl BondarenkoDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Yali WangDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0002-4648-0711
Antonio SumaInstitute for Computational Molecular Science, College of Science and Technology, Temple University, Philadelphia, PA 19122.ORCID 0000-0002-5049-9255
Marta WellsDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Qiang ChenDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Tommy TillmanDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Yan LuoDepartment of Anesthesiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China.ORCID 0000-0003-0431-3162
Buwei YuDepartment of Anesthesiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China.ORCID 0000-0001-8975-5394
William P DaileyDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-5554-6698
Roderic EckenhoffDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Pei TangDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Vincenzo CarnevaleInstitute for Computational Molecular Science, College of Science and Technology, Temple University, Philadelphia, PA 19122.ORCID 0000-0002-1918-8280
Michael L KleinInstitute for Computational Molecular Science, College of Science and Technology, Temple University, Philadelphia, PA 19122; mlklein@temple.edu xu2@pitt.edu.
Yan XuDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261; mlklein@temple.edu xu2@pitt.edu.

Funding

X-ray and Neutron Interferometry Studies of Anesthetic Interactions with VoltageP01GM055876 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI XU, YAN · 1997 to 2017
$22.4M
NMR STUDIES OF MECHANISMS OF GENERAL ANESTHESIAR01GM049202 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XU, YAN · 2000 to 2018
$3.3M
NIGMS NIH HHS P01 GM055876NIGMS NIH HHS R01 GM049202
6 · The paper itself

Abstract

Voltage-gated sodium (Na

Indexed as

Ion Channel GatingAmino Acid SequenceBacterial ProteinsBinding SitesHEK293 CellsHumansModels, MolecularMutationPropofolProtein Structure, SecondarySodium ChannelsStructure-Activity RelationshipBacterial ProteinsNaChBac protein, bacteriaPropofolSodium Channelsgeneral anesthesiaNaChBacNMRpropofolsaturation transfer difference

Identifiers

PMID34260401
PMCPMC8285963

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.