ReviewNature reviews. Endocrinology2021
Potential gut-brain mechanisms behind adverse mental health outcomes of bariatric surgery.
Review in Nature reviews. Endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06491069 (Depression, Anxiety and Eating Disorder After Bariatric Surgery), which is not on this map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Depression, Anxiety and Eating Disorder After Bariatric Surgery
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Depressive symptoms at short-, medium-, and long-term follow-up after bariatric surgical procedures: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Bariatric Surgery and New-Onset Substance Use Disorders: A Systematic review and Meta-analysis.Obesity surgery · 2024Pooled it
- Bariatric surgery and mental health outcomes: an umbrella review.Frontiers in endocrinology · 2023Pooled it
- Beyond bariatric surgery and weight loss medicaments. A systematic review of the current practice in obesity rehabilitative inpatient programs in adults and pediatrics.Frontiers in nutrition · 2022Pooled it
- Sleeve Gastrectomy Versus Banded Roux-en-Y Gastric Bypass for Obesity and Diabetes Mellitus: Psychology and Quality of Life Outcomes at 10 Years.Obesity surgery · 2026Trial
- Trial
- Baseline Mental Health Status and Early Psychiatric Outcomes after Metabolic-Bariatric Surgery: A Retrospective Cohort Study.Obesity surgery · 2026Article
- Psychiatric Complications After Bariatric Surgery: A Narrative Review.The Eurasian journal of medicine · 2026Article
- A Contemporary Perspective on Long-Term Complications of Bariatric Surgery.Obesity surgery · 2026Review
- Metabolic and Bariatric Surgery and Depression in US Adults: A Cross-Sectional Analysis of NHANES 2015-2018.Obesity surgery · 2026Article
- Mood Disorders, Metabolic Bariatric Surgery, and Weight Loss Pharmacotherapy: a Research Update.Current obesity reports · 2025Review
- Unveiling the rumen-microbiome-brain circuit: a unique dimension of gut-brain axis in ruminants.Journal of animal science and biotechnology · 2025Review
- Mental health outcomes in bariatric surgery patients in Saudi Arabia: A scoping review.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2025Article
- PET/fMRI demonstrates that bariatric surgery may reverse striatal dopaminergic dysfunction in women with obesity.Communications medicine · 2025Article
- Early Impact of Bariatric Surgery on Brain Functionality.Journal of metabolic and bariatric surgery · 2025Review
- Psychiatric Comorbidities Associated with Food Addiction in Post-Bariatric Patients: Toward Personalized Mental Health Screening and Postoperative Care.Journal of personalized medicine · 2025Article
- Comparative impact of different weight loss strategies on obstructive sleep apnea: an integrated review of surgical, pharmacological, and lifestyle interventions.Frontiers in neurology · 2025Review
- Hypothalamic ghrelin receptors, weight loss, and glycemia in an experimentally induced obesity model treated by sleeve gastrectomy.Acta cirurgica brasileira · 2025Article
- Self-Harm Before and Six Months After Obesity Surgery.Obesity surgery · 2024Article
- Reduction of cardiovascular complications during delivery hospitalization in patients undergoing bariatric procedures.International journal of obesity (2005) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bariatric surgery induces sustained weight loss and metabolic benefits via notable effects on the gut-brain axis that lead to alterations in the neuroendocrine regulation of appetite and glycaemia. However, in a subset of patients, bariatric surgery is associated with adverse effects on mental health, including increased risk of suicide or self-harm as well as the emergence of depression and substance use disorders. The contributing factors behind these adverse effects are not well understood. Accumulating evidence indicates that there are important links between gut-derived hormones, microbial and bile acid profiles, and disorders of mood and substance use, which warrant further exploration in the context of changes in gut-brain signalling after bariatric surgery. Understanding the basis of these adverse effects is essential in order to optimize the health and well-being of people undergoing treatment for obesity.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.