ReviewFrontiers in physiology2021
Insulin-Like Peptides and Cross-Talk With Other Factors in the Regulation of Insect Metabolism.
Review in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 111 citations in OpenAlex.
- Identification and Potential Functions of MicroRNAs Involved in Freshwater Adaptation in Aquatic FireflyInsects · 2026Article
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- Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Metabolic and behavioral effects of neurofibromin result from differential recruitment of MAPK and mTOR signaling.PLoS genetics · 2026Article
- Functional genomics reveals key gene families and molecular pathways for extreme cold survival in the khapra beetle.BMC biology · 2026Article
- Gene family-level endocrine compensation and metabolic reprogramming preserve growth homeostasis under sustained insulin-like peptide suppression inFrontiers in endocrinology · 2026Article
- Tachykinin-related peptide signalling is important for the immune response of the mealworm beetleFrontiers in immunology · 2026Article
- Lipid Metabolism in Relation to Carbohydrate Metabolism.Advances in experimental medicine and biology · 2026Review
- Insect Lipids: Structure, Classification and Function.Advances in experimental medicine and biology · 2026Review
- Lipids in Insect Reproduction: Where, How, and Why.Advances in experimental medicine and biology · 2026Review
- Trehalose metabolism: an integrative hub linking energy homeostasis and development in insects.Frontiers in insect science · 2026Review
- Transcriptional regulation of neuropeptide receptors underlies context-dependent adaptation in Drosophila melanogaster.FEBS open bio · 2026Article
- Insect neuropeptides as agents for pest control: potential and challenges.Biological research · 2025Review
- An insulin-like peptide mediates trehalose storage in the western tarnished plant bug, Lygus hesperus.Journal of insect physiology · 2025Article
- Characteristics of the Insulin-like Peptide Genes and Their Roles in the Ovarian Development ofInsects · 2025Article
- An ovarian insulin-like peptide specifically regulates energy allocation and oocyte development in nutrition-restricted cockroaches.BMC biology · 2025Article
- Venom IMP-L2 from the EctoparasitoidInsects · 2025Article
- The foraging gene coordinates brain and heart networks to modulate socially cued interval timing in Drosophila.PLoS genetics · 2025Article
- Transcriptome-Wide Identification of Neuropeptides and Neuropeptide Receptors in the Twenty-Eight-Spotted LadybirdInsects · 2025Article
- Nature's blueprint for sugar metabolism: translating bee and ant strategies into human diabetes therapies.Diabetology & metabolic syndrome · 2025Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The insulin-like peptide (ILP) and insulin-like growth factor (IGF) signalling pathways play a crucial role in the regulation of metabolism, growth and development, fecundity, stress resistance, and lifespan. ILPs are encoded by multigene families that are expressed in nervous and non-nervous organs, including the midgut, salivary glands, and fat body, in a tissue- and stage-specific manner. Thus, more multidirectional and more complex control of insect metabolism can occur. ILPs are not the only factors that regulate metabolism. ILPs interact in many cross-talk interactions of different factors, for example, hormones (peptide and nonpeptide), neurotransmitters and growth factors. These interactions are observed at different levels, and three interactions appear to be the most prominent/significant: (1) coinfluence of ILPs and other factors on the same target cells, (2) influence of ILPs on synthesis/secretion of other factors regulating metabolism, and (3) regulation of activity of cells producing/secreting ILPs by various factors. For example, brain insulin-producing cells co-express sulfakinins (SKs), which are cholecystokinin-like peptides, another key regulator of metabolism, and express receptors for tachykinin-related peptides, the next peptide hormones involved in the control of metabolism. It was also shown that ILPs in
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.