Evidence map›Paper›PMID 34268113›Full record

ArticleFrontiers in oncology2021

PI3K Promotes Basal Cell Carcinoma Growth Through Kinase-Induced p21 Degradation.

Rachel Y Chow, Ung Seop Jeon, Taylor M Levee, Gurleen Kaur, Daniel P Cedeno, Linda T Doan, Scott X Atwood

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rachel Y ChowDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, United States.
Ung Seop JeonDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, United States.
Taylor M LeveeDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, United States.
Gurleen KaurDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, United States.
Daniel P CedenoDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, United States.
Linda T DoanDepartment of Dermatology, University of California, Irvine, Irvine, CA, United States.
Scott X AtwoodDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, United States.
University of California, Irvine · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1M
Phosphorylation-dependent regulation of GLI transcription factorsR01CA237563 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI ATWOOD, SCOTT · 2019 to 2023
$1.7M
NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA237563NIAMS NIH HHS P30 AR075047
6 · The paper itself

Abstract

Basal cell carcinoma (BCC) is a locally invasive epithelial cancer that is primarily driven by the Hedgehog (HH) pathway. Advanced BCCs are a critical subset of BCCs that frequently acquire resistance to Smoothened (SMO) inhibitors and identifying pathways that bypass SMO could provide alternative treatments for patients with advanced or metastatic BCC. Here, we use a combination of RNA-sequencing analysis of advanced human BCC tumor-normal pairs and immunostaining of human and mouse BCC samples to identify a PI3K pathway expression signature in BCC. Pharmacological inhibition of PI3K activity in BCC cells significantly reduces cell proliferation and HH signaling. However, treatment of

Indexed as

atypical PKCιbasal cell carcinomahedgehogp21PI3K - AKT pathway

Identifiers

PMID34268113
PMCPMC8276170
OpenAlexW3176815830

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.