Evidence mapPaperPMID 34268461Full record

ArticleJournal of the Endocrine Society2021

The Effect of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Therapy on Skeletal Muscle Lipid Content in Obese and Nonobese Men.

Alexander M Koenig, Ulrich Koehler, Olaf Hildebrandt, Hans Schwarzbach, Lena Hannemann, Raphael Boneberg, Johannes T Heverhagen, Andreas H Mahnken, Malte Keller, Peter H Kann and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Approach the Patient With Obstructive Sleep Apnea and Obesity.The Journal of clinical endocrinology and metabolism · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Alexander M KoenigDepartment of Diagnostic and Interventional Radiology, University Hospital of Marburg, Philipps-University of Marburg, 35043 Marburg, Germany.
Ulrich KoehlerDepartment of Sleep Medicine, Division of Pneumology, Internal Medicine, University Hospital, Philipps-University of Marburg, 35043 Marburg, Germany.
Olaf HildebrandtDepartment of Sleep Medicine, Division of Pneumology, Internal Medicine, University Hospital, Philipps-University of Marburg, 35043 Marburg, Germany.
Hans SchwarzbachDepartment of Medical Cell Biology, Institute for Anatomy and Cell Biology, Philipps-University of Marburg, 35032 Marburg, Germany.
Lena HannemannDepartment of Medical Cell Biology, Institute for Anatomy and Cell Biology, Philipps-University of Marburg, 35032 Marburg, Germany.
Raphael BonebergDepartment of Medical Cell Biology, Institute for Anatomy and Cell Biology, Philipps-University of Marburg, 35032 Marburg, Germany.
Johannes T HeverhagenDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Andreas H MahnkenDepartment of Diagnostic and Interventional Radiology, University Hospital of Marburg, Philipps-University of Marburg, 35043 Marburg, Germany.
Malte KellerDepartment of Diagnostic and Interventional Radiology, University Hospital of Marburg, Philipps-University of Marburg, 35043 Marburg, Germany.
Peter H KannDivision of Endocrinology, Diabetology and Osteology, Internal Medicine, University Hospital, Philipps-University of Marburg, 35043 Marburg, Germany.
Hans-Peter DeignerFurtwangen University, Institute of Precision Medicine, 78054 VS-Schwenningen, Germany.
Nico LaurDepartment of Medical Cell Biology, Institute for Anatomy and Cell Biology, Philipps-University of Marburg, 35032 Marburg, Germany.
Ralf KinscherfDepartment of Medical Cell Biology, Institute for Anatomy and Cell Biology, Philipps-University of Marburg, 35032 Marburg, Germany.
Wulf HildebrandtDepartment of Medical Cell Biology, Institute for Anatomy and Cell Biology, Philipps-University of Marburg, 35032 Marburg, Germany.ORCID https://orcid.org/0000-0002-4614-841X
Philipps University of Marburg · DEFurtwangen University · DEUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obstructive sleep apnea (OSA), independently of obesity (OBS), predisposes to insulin resistance (IR) for largely unknown reasons. Because OSA-related intermittent hypoxia triggers lipolysis, overnight increases in circulating free fatty acids (FFAs) including palmitic acid (PA) may lead to ectopic intramuscular lipid accumulation potentially contributing to IR. Using 3-T-

Indexed as

aerobic capacitydiabetesectopic fatintermittent hypoxiaobesity

Identifiers

PMID34268461
PMCPMC8274947
OpenAlexW3162200967

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.