Evidence mapPaperPMID 34269010Full record

ArticleJournal of Zhejiang University. Science. B2021

Inhibitory mechanism of angiotensin-converting enzyme inhibitory peptides from black tea.

Yating Lu, Yu Wang, Danyi Huang, Zhuang Bian, Peng Lu, Dongmei Fan, Xiaochang Wang

Open access · greenAbstract read
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yating LuTea Research Institute, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Yu WangTea Research Institute, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Danyi HuangTea Research Institute, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Zhuang BianTea Research Institute, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Peng LuDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Dongmei FanTea Research Institute, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Xiaochang WangTea Research Institute, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Tea Research Institute · CNThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this work is to discover the inhibitory mechanism of tea peptides and to analyse the affinities between the peptides and the angiotensin-converting enzyme (ACE) as well as the stability of the complexes using in vitro and in silico methods. Four peptide sequences identified from tea, namely peptides I, II, III, and IV, were used to examine ACE inhibition and kinetics. The half maximal inhibitory concentration (IC

Indexed as

TeaAllosteric SiteAngiotensin-Converting Enzyme InhibitorsAnimalsCatalytic DomainFoodHydrogen BondingInhibitory Concentration 50KineticsMolecular ConformationMolecular Docking SimulationMolecular Dynamics SimulationPeptidesPeptidyl-Dipeptidase ARabbitsACE protein, humanAngiotensin-Converting Enzyme InhibitorsPeptidesPeptidyl-Dipeptidase ATeaAngiotensin-1-converting enzyme (ACE) inhibitory peptideBlack teaKinetic studyMolecular dockingMolecular dynamic (MD) simulation

Identifiers

PMID34269010
PMCPMC8284085
OpenAlexW3179934112

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.