Evidence map›Paper›PMID 34270325›Full record

Trial reportCirculation. Genomic and precision medicine2021

Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations.

Danielle E Haslam, Gina M Peloso, Melanie Guirette, Fumiaki Imamura, Traci M Bartz, Achilleas N Pitsillides, Carol A Wang, Ruifang Li-Gao, Jason M Westra, Niina Pitkänen and 46 more

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Genomic and precision medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors at 20 institutions in 9 countries.

Danielle E HaslamNutritional Epidemiology Program (D.E.H., M. Guirette, K.A.L., N.M.M.), Tufts University, Boston, MA.
Gina M PelosoDepartment of Biostatistics, Boston University School of Public Health, MA (G.M.P., A.N.P., J.D.).
Melanie GuiretteNutritional Epidemiology Program (D.E.H., M. Guirette, K.A.L., N.M.M.), Tufts University, Boston, MA.
Fumiaki ImamuraMedical Research Council Epidemiology Unit, University of Cambridge, United Kingdom (F.I., J.L., N.G.F., N.J.W.).
Traci M BartzCardiovascular Health Research Unit, Departments of Biostatistics (T.M.B.), University of Washington, Seattle.
Achilleas N PitsillidesDepartment of Biostatistics, Boston University School of Public Health, MA (G.M.P., A.N.P., J.D.).
Carol A WangSchool of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, NSW, Australia (C.A.W., C.E.P.).
Ruifang Li-GaoDepartment of Clinical Epidemiology (R.L.G., D.O.M.-K., F.R.R., R.dM.), Leiden University Medical Center, the Netherlands.
Jason M WestraDordt University, Sioux Center, IA (J.M.W., N.T.).
Niina PitkänenAuria Biobank (N.P.), University of Turku, Finland.
Kristin L YoungDepartment of Epidemiology, Gillings School of Global Public Health (K.L.Y., M. Graff, K.N.), University of North Carolina, Chapel Hill.
Mariaelisa GraffDepartment of Epidemiology, Gillings School of Global Public Health (K.L.Y., M. Graff, K.N.), University of North Carolina, Chapel Hill.
Alexis C WoodUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX (A.C.W.).
Kim V E BraunDepartment of Epidemiology (K.V.E.B., J.C.K.-d.J., M. Ghanbari, M.A.I.), Erasmus MC University Medical Center Rotterdam, the Netherlands.
Jian'an LuanMedical Research Council Epidemiology Unit, University of Cambridge, United Kingdom (F.I., J.L., N.G.F., N.J.W.).
Mika KähönenDepartment of Clinical Physiology (M.K.), Tampere University Hospital, Finland.
Jessica C Kiefte-de JongDepartment of Public Health and Primary Care (J.C.L.d.J., D.O.M.-K.), Leiden University Medical Center, the Netherlands.
Mohsen GhanbariDepartment of Epidemiology (K.V.E.B., J.C.K.-d.J., M. Ghanbari, M.A.I.), Erasmus MC University Medical Center Rotterdam, the Netherlands.
Nathan TintleDordt University, Sioux Center, IA (J.M.W., N.T.).
Rozenn N LemaitreDepartment of Medicine (T.M.B., R.N.L., B.M.P.), University of Washington, Seattle.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology (R.L.G., D.O.M.-K., F.R.R., R.dM.), Leiden University Medical Center, the Netherlands.
Kari NorthDepartment of Epidemiology, Gillings School of Global Public Health (K.L.Y., M. Graff, K.N.), University of North Carolina, Chapel Hill.
Mika HelminenResearch Development and Innovation Centre (M.H.), Tampere University Hospital, Finland.
Yasmin Mossavar-RahmaniDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.M.-R.).
Linda SnetselaarDepartment of Epidemiology, University of Iowa, Iowa City (L.S.).
Lisa W MartinGeorge Washington University School of Medicine and Health Sciences, Washington, D.C. (L.W.M.).
Jorma S ViikariDepartment of Medicine (J.S.V.), University of Turku, Finland.
Wendy H OddyMenzies Institute for Medical Research, University of Tasmania, HOB, Australia (W.H.O.).
Craig E PennellNutrition and Genomics Laboratory (C.E.S.), Tufts University, Boston, MA.
Frits R RosendallDepartment of Clinical Epidemiology (R.L.G., D.O.M.-K., F.R.R., R.dM.), Leiden University Medical Center, the Netherlands.
M Arfan IkramDepartment of Epidemiology (K.V.E.B., J.C.K.-d.J., M. Ghanbari, M.A.I.), Erasmus MC University Medical Center Rotterdam, the Netherlands.
Andre G UitterlindenDepartment of Internal Medicine (A.G.U.), Erasmus MC University Medical Center Rotterdam, the Netherlands.
Bruce M PsatyDepartment of Medicine (T.M.B., R.N.L., B.M.P.), University of Washington, Seattle.
Dariush MozaffarianJean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, and Friedman School of Nutrition Science and Policy (D.M.), Tufts University, Boston, MA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.I.R., K.D.T.).
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.I.R., K.D.T.).
Terho LehtimäkiDepartment of Clinical Chemistry (T.L.), Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Finland.
Olli T RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), University of Turku, Finland.
Kara A LivingstonNutritional Epidemiology Program (D.E.H., M. Guirette, K.A.L., N.M.M.), Tufts University, Boston, MA.
Trudy Voortman
Nita G ForouhiMedical Research Council Epidemiology Unit, University of Cambridge, United Kingdom (F.I., J.L., N.G.F., N.J.W.).
Nick J WarehamMedical Research Council Epidemiology Unit, University of Cambridge, United Kingdom (F.I., J.L., N.G.F., N.J.W.).
Renée de MutsertDepartment of Clinical Epidemiology (R.L.G., D.O.M.-K., F.R.R., R.dM.), Leiden University Medical Center, the Netherlands.
Steven S RichCenter for Public Health Genomics and Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville (S.S.R.).
JoAnn E MansonChanning Division of Network Medicine (D.E.H., J.E.M.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Samia MoraDivision of Preventive Medicine (J.E.M., S.M., P.M.R., D.I.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Paul M RidkerDivision of Preventive Medicine (J.E.M., S.M., P.M.R., D.I.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Jordi MerinoProgram in Medical and Population Genetics (J.M., J.B.M., H.S.D.), Broad Institute of MIT and Harvard, Cambridge, MA.
James B MeigsProgram in Medical and Population Genetics (J.M., J.B.M., H.S.D.), Broad Institute of MIT and Harvard, Cambridge, MA.
Hassan S DashtiProgram in Medical and Population Genetics (J.M., J.B.M., H.S.D.), Broad Institute of MIT and Harvard, Cambridge, MA.
Daniel I ChasmanDivision of Preventive Medicine (J.E.M., S.M., P.M.R., D.I.C.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Alice H LichtensteinCardiovascular Nutrition Laboratory (A.H.L.), Tufts University, Boston, MA.
Caren E Smith
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, MA (G.M.P., A.N.P., J.D.).
Mark A HermanDivision Of Endocrinology, Metabolism, and Nutrition, Department of Medicine and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC (M.A.H.).
Nicola M McKeownNutritional Epidemiology Program (D.E.H., M. Guirette, K.A.L., N.M.M.), Tufts University, Boston, MA.
Tufts University · USLeiden University Medical Center · NLBrigham and Women's Hospital · USErasmus MC · NLMedical Research Council · GBBoston University · USBroad Institute · USDepartment of Health · ZADordt University · USTampere University Hospital · FIUCLA Medical Center · USUniversity of Turku · FIUniversity of Washington · USAlbert Einstein College of Medicine · USChildren's Nutrition Research Center at Baylor College of Medicine · USDuke University · USGeorge Washington University · USJean Mayer Human Nutrition Research Center on Aging · USKaiser Permanente Washington Health Research Institute · USOffice of Public Health Genomics · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Women's Health Study: Infrastructure support for continued cohort follow-upU01CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2019 to 2023
$4.0M
TOPMed Omics of Type 2 Diabetes and Quantitative TraitsUM1DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MANNING, ALISA KNODLE · 2021 to 2025
$3.8M
The Role of ChREBP in Fructose Induced Metabolic DiseaseR01DK100425 · NIDDK · DUKE UNIVERSITY · PI HERMAN, MARK A · 2014 to 2023
$3.6M
TOPMed Omics of Cardiovascular Disease in DiabetesR01HL151855 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2020 to 2023
$3.3M
Mechanisms connecting dysregulated BCAA, glucose & lipid metabolism in the pathogenesis of metabolic diseaseR01DK121710 · NIDDK · DUKE UNIVERSITY · PI HERMAN, MARK A, NEWGARD, CHRISTOPHER B · 2019 to 2022
$2.7M
Nutrition &Cardiovascular Disease Training ProgramT32HL069772 · NHLBI · TUFTS UNIVERSITY BOSTON · PI LICHTENSTEIN, ALICE H · 2003 to 2017
$2.1M
Semiparametric Analysis of Big Censored DataR01HL149683 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, DANYU · 2020 to 2023
$1.9M
Analyzing the behavior and interpreting the results of gene based tests of rare variant associationR15HG006915 · NHGRI · DORDT COLLEGE · PI TINTLE, NATHAN L · 2012 to 2020
$1.3M
Genetic predictors of metabolic responses to dairyK08HL112845 · NHLBI · TUFTS UNIVERSITY BOSTON · PI SMITH, CAREN ELIZABETH · 2013 to 2017
$474k
American Heart Association-American Stroke Association 16CSA28590003-HERMANMedical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_00006/1Medical Research Council MC_UU_00006/3NCI NIH HHS T32 CA009001NCI NIH HHS U01 CA182913NHGRI NIH HHS R15 HG006915NHLBI NIH HHS K08 HL112845NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL149683NHLBI NIH HHS R01 HL151855NHLBI NIH HHS T32 HL069772NIDDK NIH HHS R01 DK100425NIDDK NIH HHS R01 DK121710NIDDK NIH HHS UM1 DK078616NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

backgroundChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the

methodsData from 11 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (N=63 599) and the UK Biobank (N=59 220) were used to quantify associations of SSB consumption, genetic variants, and their interaction on HDL-C and triglyceride concentrations using linear regression models. A total of 1606 single nucleotide polymorphisms within or near

resultsIn a meta-analysis, rs71556729 was significantly associated with higher HDL-C concentrations only among the highest SSB consumers (β, 2.12 [95% CI, 1.16-3.07] mg/dL per allele;

conclusionsOur results identified genetic variants in the

Indexed as

Polymorphism, Single NucleotideAdultBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCholesterol, HDLFemaleHumansMaleMeta-Analysis as TopicMiddle AgedSugar-Sweetened BeveragesTriglyceridesBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCholesterol, HDLMLXIPL protein, humanTriglyceridescarbohydratesdyslipidemiaepidemiologygeneticsnutritionsugarstriglyceride

Identifiers

PMID34270325
PMCPMC8373451
OpenAlexW3183003276

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.