ArticleCardiovascular diabetology2021
Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study.
Article in Cardiovascular diabetology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 4 of them syntheses that pooled it.
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Who cites it
133 citing papers in PubMed, 4 syntheses or guidelines pooled it, 240 citations in OpenAlex.
- Investigating the association between the triglyceride-glucose index and peripheral artery disease: a systematic review and meta-analysis.Nutrition & diabetes · 2024Pooled it
- Dose-response associations of triglyceride to high-density lipoprotein cholesterol ratio and triglyceride-glucose index with arterial stiffness risk.Lipids in health and disease · 2024Pooled it
- Association between triglyceride glucose index and arterial stiffness and coronary artery calcification: a systematic review and exposure-effect meta-analysis.Cardiovascular diabetology · 2023Pooled it
- The impact of triglyceride-glucose index on ischemic stroke: a systematic review and meta-analysis.Cardiovascular diabetology · 2023Pooled it
- Association between triglyceride-glucose index and elevated blood pressure among U.S. adolescents aged 12-17.Pediatric research · 2026Article
- Association Between the Preoperative Triglyceride-Glucose Index and Intraoperative Blood Pressure Variability in Major Abdominal Surgery: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Identification and Optimization of Risk for Stroke With Abdominal Obesity Patients: Insights From NHANES 2005-2018.Obesity science & practice · 2026Article
- Machine learning evaluation of TyG-based metrics for arteriosclerosis progression.Scientific reports · 2026Article
- Impact of Cardiometabolic Risk Markers on the Incidence and Progression Arterial Stiffness in Patients With Prediabetes.Journal of diabetes · 2026Article
- Triglyceride Glucose-Body Mass Index Is Related With Arterial Stiffness in Adults: A Cross-Sectional Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Associations of Lipid and Adiposity Indices with Vascular Aging Stages in a Multicenter Chinese Population.Current medical science · 2026Article
- A machine learning model based on routine blood-derived indices for early arterial stiffness prediction in the community.Lipids in health and disease · 2026Article
- The association between the glucose-lipid metabolism index and the cardiovascular disease prevalence of prediabetes and diabetes participants: evidence from NHANES 2001-2018.BMC endocrine disorders · 2026Article
- Association of triglyceride-glucose index with carotid atherosclerosis in the general population: a case-control study of 14,535 participants.BMC cardiovascular disorders · 2026Article
- Brachial-Ankle Pulse Wave Velocity Is Associated with Kidney Function Decline in Adults Undergoing Cardiovascular Disease Screening.Kidney360 · 2026Article
- Association between the triglyceride-glucose index and the risk of post-stroke depression.Frontiers in psychiatry · 2026Article
- Article
- Association between Phase Angle and Subclinical Atherosclerosis in Asymptomatic Adults: A Large Scale Cross-Sectional and Longitudinal Study.Journal of atherosclerosis and thrombosis · 2026Article
- A Nonlinear Association Between Gamma-Glutamyltransferase to High-Density Lipoprotein Cholesterol Ratio and Arterial Stiffness in Japanese Population: A Secondary Analysis Based on a Cross-Sectional Study.Vascular health and risk management · 2026Article
- Effect modification by fatty liver in the association between triglyceride-Glucose index and new-onset hypertension: a large health-examination cohort study.Frontiers in endocrinology · 2026Article
73 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTriglyceride-glucose (TyG) index, a simple surrogate marker of insulin resistance, has been reported to be associated with arterial stiffness. However, previous studies were limited by the cross-sectional design. The purpose of this study was to explore the longitudinal association between TyG index and progression of arterial stiffness.
methodsA total of 6028 participants were derived from the Kailuan study. TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Arterial stiffness progression was assessed by the annual growth rate of repeatedly measured baPWV. Multivariate linear regression models were used to estimate the cross-sectional association of TyG index with baPWV, and Cox proportional hazard models were used to investigate the longitudinal association between TyG index and the risk of arterial stiffness.
resultsMultivariate linear regression analyses showed that each one unit increase in the TyG index was associated with a 39 cm/s increment (95%CI, 29-48 cm/s, P < 0.001) in baseline baPWV and a 0.29 percent/year increment (95%CI, 0.17-0.42 percent/year, P < 0.001) in the annual growth rate of baPWV. During 26,839 person-years of follow-up, there were 883 incident cases with arterial stiffness. Participants in the highest quartile of TyG index had a 58% higher risk of arterial stiffness (HR, 1.58; 95%CI, 1.25-2.01, P < 0.001), as compared with those in the lowest quartile of TyG index. Additionally, restricted cubic spline analysis showed a significant dose-response relationship between TyG index and the risk of arterial stiffness (P non-linearity = 0.005).
conclusionParticipants with a higher TyG index were more likely to have a higher risk of arterial stiffness. Subjects with a higher TyG index should be aware of the following risk of arterial stiffness progression, so as to establish lifestyle changes at an early stage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.