Evidence map›Paper›PMID 34272257›Full record

ArticleeNeuro

Forebrain Neural Precursor Cells Are Differentially Vulnerable to Zika Virus Infection.

Samantha M Shelton, Alexandra R Soucy, Ronni Kurzion, Ella Zeldich, John H Connor, Tarik F Haydar

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Samantha M SheltonDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118.ORCID 0000-0003-0869-461X
Alexandra R SoucyDepartment of Microbiology and National Emerging Infectious Diseases Laboratories, Boston University Medical Campus, Boston, MA 02118.
Ronni KurzionDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118.
Ella ZeldichDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118.
John H ConnorDepartment of Microbiology and National Emerging Infectious Diseases Laboratories, Boston University Medical Campus, Boston, MA 02118.
Tarik F HaydarDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118 thaydar@childrensnational.org.ORCID 0000-0001-6772-3076
Boston University · US

Funding

Assessment of infection route and vulnerability of neural precursor classes to Zika virusR21NS101151 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CONNOR, JOHN H, HAYDAR, TARIK F · 2016 to 2017
$452k
NINDS NIH HHS R21 NS101151
6 · The paper itself

Abstract

Prenatal exposure to Zika virus (ZIKV) can result in microencephaly and congenital Zika syndrome, although some brain cells and structures are spared by the virus for unknown reasons. Here, a novel murine model of fetal ZIKV infection incorporating intraventricular infection and cell type-specific

Indexed as

MicrocephalyNeural Stem CellsZika VirusZika Virus InfectionAnimalsFemaleMicePregnancyProsencephaloncorticogenesisdevelopmentheterogeneitymicrocephalyradial gliaZika

Identifiers

PMID34272257
PMCPMC8431824
OpenAlexW3179228142

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.