Evidence map›Paper›PMID 34272437›Full record

Observational studyScientific reports2021

Trajectories in glycated hemoglobin and body mass index in children and adolescents with diabetes using the common data model.

Yun Jeong Lee, Sooyoung Yoo, Soyoung Yi, Seok Kim, Chunggak Lee, Jihoon Cho, Soyeon Ahn, Sunkyu Choi, Hee Hwang, Young Ah Lee and 11 more

Open access · goldFull text readObservational Study
In one paragraph

Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 1 country.

Yun Jeong LeeDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
Sooyoung YooOffice of eHealth Research and Businesses, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Soyoung YiOffice of eHealth Research and Businesses, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Seok KimOffice of eHealth Research and Businesses, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Chunggak LeeOffice of eHealth Research and Businesses, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Jihoon ChoOffice of eHealth Research and Businesses, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Soyeon AhnDivision of Statistics, Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Sunkyu ChoiDivision of Statistics, Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.
Hee HwangDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
Young Ah LeeDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
Choong Ho ShinDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
Hyung-Jin YoonDepartment of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea.
Kwangsoo KimTransdisciplinary Department of Medicine and Advanced Technology, Seoul National University Hospital, Seoul, Korea.
Eunhye SongDepartment of Data Science Research, Innovative Medical Technology Research Institute, Seoul National University Hospital, Seoul, Korea.
Jin Ho ChoiDepartment of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Han Wook YooDepartment of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Young-Hak KimDepartment of Information Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Ji Seon OhDepartment of Information Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Eun-Ae KangHealth Innovation Big Data Center, Asan Institute of Life Sciences, Asan Medical Center, Seoul, Korea.
Ga Kyoung BaekHealth Innovation Big Data Center, Asan Institute of Life Sciences, Asan Medical Center, Seoul, Korea.
Jae Hyun KimDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. pedendo@snubh.org.
Seoul National University Bundang Hospital · KRAsan Medical Center · KRSeoul National University · KRSeoul National University Hospital · KRUlsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated trajectories of glycated hemoglobin (HbA1c) levels and body mass index z-scores (BMIz) for 5 years after diagnosis among Korean children and adolescents with type 1 diabetes (T1D) or type 2 diabetes (T2D) using the common data model. From the de-identified database of three hospitals, 889 patients < 15 years of age diagnosed with T1D or T2D (393 boys, 664 T1D patients) were enrolled. Diagnosis was defined as first exposure to antidiabetic drug at each center. Compared with T2D patients, T1D patients had lower BMIz at diagnosis (- 0.4 ± 1.2 vs. 1.5 ± 1.4, p < 0.001) and 3 months (- 0.1 ± 1.0 vs. 1.5 ± 1.5, p < 0.001), and higher HbA1c levels at diagnosis (10.0 ± 2.6% vs. 9.5 ± 2.7%, p < 0.01). After 3 months, HbA1c levels reached a nadir of 7.6% and 6.5% in T1D and T2D patients, respectively, followed by progressive increases; only 10.4% of T1D and 29.7% of T2D patients achieved the recommended HbA1c target (< 7.0%) at 60 months. T1D patients showed consistent increases in BMIz; T2D patients showed no significant change in BMIz during follow-up. Peri-pubertal girls with T1D had higher HbA1c and BMIz values. Achieving optimal glycemic control and preventing obesity should be emphasized in pediatric diabetes care.

Indexed as

AdolescentBody Mass IndexChildChild, PreschoolCommon Data ElementsDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleFollow-Up StudiesGlycated HemoglobinHumansInfantInfant, NewbornInsulinMaleMetforminGlycated Hemoglobinhemoglobin A1c protein, humanInsulinMetformin

Identifiers

PMID34272437
PMCPMC8285411
OpenAlexW3182520756

What Socratic holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.