Evidence map›Paper›PMID 34278178›Full record

ArticleHepatology communications2021

Dual-Specificity Phosphatase 9 Regulates Cellular Proliferation and Predicts Recurrence After Surgery in Hepatocellular Carcinoma.

Kui Chen, Andre Gorgen, Avrilynn Ding, Lulu Du, Keruo Jiang, Yu Ding, Gonzalo Sapisochin, Anand Ghanekar

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kui ChenToronto General Hospital Research InstituteUniversity Health NetworkTorontoONCanada.
Andre GorgenDivision of General SurgeryUniversity Health NetworkTorontoONCanada.ORCID 0000-0002-8588-2107
Avrilynn DingToronto General Hospital Research InstituteUniversity Health NetworkTorontoONCanada.
Lulu DuToronto General Hospital Research InstituteUniversity Health NetworkTorontoONCanada.
Keruo JiangToronto General Hospital Research InstituteUniversity Health NetworkTorontoONCanada.
Yu DingToronto General Hospital Research InstituteUniversity Health NetworkTorontoONCanada.
Gonzalo SapisochinDivision of General SurgeryUniversity Health NetworkTorontoONCanada.
Anand GhanekarToronto General Hospital Research InstituteUniversity Health NetworkTorontoONCanada.
University Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (CC) is a common and deadly cancer with complex molecular pathogenesis. Little is known about dual-specificity phosphatases (DUSPs) in HCC. We investigated DUSP9 expression in human HCC, associations between DUSP9 and patient outcomes, and effects of altered DUSP9 expression on HCC biology. We studied public data sets as well as 196 patients at our institution who had HCC resections. Quantitative real-time reverse transcription polymerase chain reaction and western blot demonstrated that

Identifiers

PMID34278178
PMCPMC8279460
OpenAlexW3138155787

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.