Evidence map›Paper›PMID 34278447›Full record

ArticleInternational journal of molecular medicine2021

Astragaloside IV ameliorates diabetic nephropathy in

Hui Feng, Xiaoyun Zhu, Yang Tang, Shouqiang Fu, Bingtan Kong, Ximing Liu

Open access · hybridAbstract read
In one paragraph

Article in International journal of molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Terpenes in the management of chronic kidney disease.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Experimental and therapeutic medicine · 2023
    Article
  18. Review
  19. Efficacy of Danggui Buxue decoction on diabetic nephropathy-induced renal fibrosis in rats and possible mechanism.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Hui FengSchool of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China.
Xiaoyun ZhuDepartment of Laboratory of Diabetes, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P.R. China.
Yang TangSchool of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, P.R. China.
Shouqiang FuSchool of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, P.R. China.
Bingtan KongDepartment of Laboratory of Diabetes, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P.R. China.
Ximing LiuDepartment of Laboratory of Diabetes, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P.R. China.
Beijing University of Chinese Medicine · CNGuang’anmen Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNNanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy (DN) is a primary cause of end‑stage renal disease. Despite the beneficial effects of astragaloside IV (AS)‑IV on renal disease, the underlying mechanism of its protective effects against DN has not been fully determined. The aims of the present study were to assess the effects of AS‑IV against DN in

Indexed as

AnimalsCaspase 1Cells, CulturedCell SurvivalDiabetes Mellitus, Type 2Diabetic NephropathiesGene Expression RegulationInflammasomesInflammationInterleukin-1betaKidney CortexMaleMiceMice, Inbred C57BLMicroscopy, Electron, TransmissionNLR Family, Pyrin Domain-Containing 3 Proteinastragaloside ACaspase 1InflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinSaponinsTriterpenesastragaloside IVdiabetic nephropathyinflammationNLR family pyrin domain containing 3 inflammasomepodocyteproteinuria

Identifiers

PMID34278447
PMCPMC8262660
OpenAlexW3181307362

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.