Evidence mapPaperPMID 34279136Full record

ReviewExperimental biology and medicine (Maywood, N.J.)2021

Machine learning in optical coherence tomography angiography.

David Le, Taeyoon Son, Xincheng Yao

Open access · greenAbstract readReview
In one paragraph

Review in Experimental biology and medicine (Maywood, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  13. Emerging imaging developments in experimental vision sciences and ophthalmology.Experimental biology and medicine (Maywood, N.J.) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David LeDepartment of Bioengineering, 14681University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0003-3772-1875
Taeyoon SonDepartment of Bioengineering, 14681University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0001-7273-5880
Xincheng YaoDepartment of Bioengineering, 14681University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-0356-3242
University of Illinois Chicago · US

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · UNIVERSITY OF ILLINOIS AT CHICAGO · 1985 to 2025
$3.9M
Differential artery-vein analysis in OCT angiography for objective classification of diabetic retinopathyR01EY030842 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Jennifer Irene Lim, XINCHENG YAO · 2023 to 2023
$363k
Training program in the biology and translational research on Alzheimer's diseaseand related dementiasT32AG057468 · UNIVERSITY OF ILLINOIS AT CHICAGO · 2025 to 2025
$334k
Functional tomography of neurovascular coupling interactions in healthy and diseased retinasR01EY030101 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI XINCHENG YAO · 2022 to 2022
$304k
NEI NIH HHS P30 EY001792NEI NIH HHS R01 EY023522NEI NIH HHS R01 EY029673NEI NIH HHS R01 EY030101NEI NIH HHS R01 EY030842NIA NIH HHS T32 AG057468
6 · The paper itself

Abstract

Optical coherence tomography angiography (OCTA) offers a noninvasive label-free solution for imaging retinal vasculatures at the capillary level resolution. In principle, improved resolution implies a better chance to reveal subtle microvascular distortions associated with eye diseases that are asymptomatic in early stages. However, massive screening requires experienced clinicians to manually examine retinal images, which may result in human error and hinder objective screening. Recently, quantitative OCTA features have been developed to standardize and document retinal vascular changes. The feasibility of using quantitative OCTA features for machine learning classification of different retinopathies has been demonstrated. Deep learning-based applications have also been explored for automatic OCTA image analysis and disease classification. In this article, we summarize recent developments of quantitative OCTA features, machine learning image analysis, and classification.

Indexed as

Deep LearningAngiographyCapillariesHumansImage Processing, Computer-AssistedRetinal DiseasesRetinal VesselsTomography, Optical Coherenceartificial intelligenceconvolutional neural networkdeep learningmachine learningoptical coherence tomography angiographyRetinaretinopathy

Identifiers

PMID34279136
PMCPMC8718258
OpenAlexW3185447552

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.