ArticleMicrobial ecology2022
Genetic Diversity and Azole Resistance Among Natural Aspergillus fumigatus Populations in Yunnan, China.
Article in Microbial ecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Antifungal Susceptibility andMicroorganisms · 2026Article
- Novel Genetic Diversity and Geographic Structures ofMicroorganisms · 2026Article
- Sexual reproduction and the polygenic architecture of azole resistance in agricultural populations ofFrontiers in microbiology · 2026Article
- Research advances and public health strategies in China on WHO priority fungal pathogens.Mycology · 2025Review
- Greenhouses represent an important evolutionary niche forMicrobiology spectrum · 2024Article
- Isolation of triazole-resistantMycology · 2024Article
- Genetic structure and triazole resistance amongmSphere · 2023Article
- Antifungal susceptibility pattern ofFrontiers in microbiology · 2022Article
- Genetic Diversity and Dispersal ofGenes · 2021Article
- Historical Differentiation and Recent Hybridization in Natural Populations of the Nematode-Trapping FungusMicroorganisms · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
The emergence and spread of azole resistance alleles in clinical and environmental isolates of Aspergillus fumigatus is a global human health concern and endangers the "One Health" approach in our fight against antifungal resistance (AFR) in this pathogen. A major challenge to combat AFR in A. fumigatus is the massive aerial dispersal ability of its asexual spores. Our recent fine-scale survey of greenhouse populations of A. fumigatus near Kunming, Yunnan, China, suggested that the use of azole fungicides for plant protection was likely a major driver of the high-frequency azole-resistant A. fumigatus (ARAF) in greenhouses. Here, we investigated the potential spread of those ARAF and the structure of geographic populations of A. fumigatus by analyzing 452 isolates from 19 geographic locations across Yunnan. We found lower frequencies of ARAF in these outdoor populations than those in greenhouses near Kunming, but there were abundant new alleles and new genotypes, including those associated with azole resistance, consistent with multiple independent origins of ARAF across Yunnan. Interestingly, among the four ecological niches, the sediments of a large lake near Kunming were found to have the highest frequency of ARAF (~ 43%). While most genetic variations were observed within the 19 local populations, statistically significant genetic differentiations were found between many subpopulations within Yunnan. Furthermore, similar to greenhouse populations, these outdoor populations of A. fumigatus in Yunnan were significantly different from those in other parts of the world. Our results call for increased attention to local and regional studies of this fungal pathogen to help develop targeted control strategies against ARAF.
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