Evidence map›Paper›PMID 34280322›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

DNA Methylome Alterations Are Associated with Airway Macrophage Differentiation and Phenotype during Lung Fibrosis.

Peter McErlean, Christopher G Bell, Richard J Hewitt, Zabreen Busharat, Patricia P Ogger, Poonam Ghai, Gesa J Albers, Emily Calamita, Shaun Kingston, Philip L Molyneaux and 4 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 36 citations in OpenAlex.

  1. Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026
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  11. Mechanisms and markers of lung ageing in health and disease.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
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  14. Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
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  20. Epigenomic insights into common human disease pathology.Cellular and molecular life sciences : CMLS · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Peter McErleanNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Christopher G BellWilliam Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, United Kingdom.
Richard J HewittNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0003-4294-0052
Zabreen BusharatNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Patricia P OggerNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Poonam GhaiNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Gesa J AlbersNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Emily CalamitaNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Shaun KingstonNational Institute for Health Research Clinical Research Facility, Royal Brompton Hospital, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
Philip L MolyneauxNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Stephan BeckDepartment of Cancer Biology, University College London Cancer Institute, University College London, London, United Kingdom; and.
Clare M LloydNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Toby M MaherNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0001-7192-9149
Adam J ByrneNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0003-2736-8174
Imperial College London · GBGuy's and St Thomas' NHS Foundation Trust · GBLondon Cancer · GBQueen Mary University of London · GBUniversity of Southern California · US

Funding

Department of Health CS-2013-13-017HSRD VA CDA 13-017Wellcome TrustWellcome Trust 107059/Z/15/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA MethylationEpigenesis, GeneticEpigenomePhenotypeAdultAgedAged, 80 and overBronchoalveolar Lavage FluidCase-Control StudiesCell DifferentiationFemaleGene Expression ProfilingGenetic MarkersHumansIdiopathic Pulmonary FibrosisMaleGenetic MarkersDNA methylationepigeneticsinterstitial lung diseasemonocytespathogenesis

Identifiers

PMID34280322
PMCPMC8534623
OpenAlexW3184451296

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.