Evidence map›Paper›PMID 34284336›Full record

ArticleNeuroImage. Clinical2021

Altered effective connectivity within an oculomotor control network in individuals with schizophrenia.

Matthew Lehet, Ivy F Tso, Sebastiaan F W Neggers, Ilse A Thompson, Beier Yao, René S Kahn, Katharine N Thakkar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew LehetDepartment of Psychology, Michigan State University, East Lansing, MI, USA.
Ivy F TsoDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Sebastiaan F W NeggersDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.
Ilse A ThompsonDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.
Beier YaoDepartment of Psychology, Michigan State University, East Lansing, MI, USA.
René S KahnDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Katharine N ThakkarDepartment of Psychology, Michigan State University, East Lansing, MI, USA; Department of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Psychiatry and Biobehavioral Medicine, Michigan State University, Grand Rapids, MI, USA. Electronic address: kthakkar@msu.edu.

Funding

Disrupted eye gaze perception as a biobehavioral marker of social dysfunction: An RDoC investigationR01MH122491 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TSO, IVY FEI · 2020 to 2024
$2.9M
Uncovering pathophysiological mechanisms of psychosis using the oculomotor system.R01MH112644 · NIMH · MICHIGAN STATE UNIVERSITY · PI THAKKAR, KATHARINE NATASHA · 2017 to 2020
$1.5M
Neural mechanisms of eye gaze perception in schizophreniaK23MH108823 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TSO, IVY FEI · 2016 to 2020
$894k
NIMH NIH HHS K23 MH108823NIMH NIH HHS R01 MH112644NIMH NIH HHS R01 MH122491
6 · The paper itself

Abstract

Rapid inhibition or modification of actions is a crucial cognitive ability, which is impaired in persons with schizophrenia (SZP). Primate neurophysiology studies have identified a network of brain regions that subserves control over gaze. Here, we examine effective connectivity within this oculomotor control network in SZP and healthy controls (HC). During fMRI, participants performed a stop-signal task variant in which they were instructed to saccade to a visual target (no-step trials) unless a second target appeared (redirect trials); on redirect trials, participants were instructed to inhibit the planned saccade and redirect to the new target. We compared functional responses on redirect trials to no-step trials and used dynamic causal modelling (DCM) to examine group differences in network effective connectivity. Behaviorally, SZP were less efficient at inhibiting, which was related to their employment status. Compared to HC, they showed a smaller difference in activity between redirect trials and no-step trials in frontal eye fields (FEF), supplementary eye fields (SEF), inferior frontal cortex (IFC), thalamus, and caudate. DCM analyses revealed widespread group differences in effective connectivity across the task, including different patterns of self-inhibition in many nodes in SZP. Group differences in how effective connectivity was modulated on redirect trials revealed differences between the FEF and SEF, between the SEF and IFC, between the superior colliculus and the thalamus, and self-inhibition within the FEF and caudate. These results provide insight into the neural mechanisms of inefficient inhibitory control in individuals with schizophrenia.

Indexed as

SchizophreniaAnimalsBrainBrain MappingFrontal LobeMagnetic Resonance ImagingSaccadesDynamic causal modelingEffective connectivityExecutive functionEye movementsResponse inhibitionSchizophreniaStop-signal task

Identifiers

PMID34284336
PMCPMC8313596

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.