Evidence map›Paper›PMID 34286111›Full record

ArticleBiochemistry and biophysics reports2021

In vitro radiotherapy and chemotherapy alter migration of brain cancer cells before cell death.

Michael Merrick, Michael J Mimlitz, Catherine Weeder, Haris Akhter, Allie Bray, Andrew Walther, Chisom Nwakama, Joe Bamesberger, Honour Djam, Kaamil Abid and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Michael MerrickDepartment of Physics, Creighton University, Omaha, NE, 68178, USA.
Michael J MimlitzDepartment of Physics, Creighton University, Omaha, NE, 68178, USA.
Catherine WeederDepartment of Biology, Creighton University, Omaha, NE, 68178, USA.
Haris AkhterDepartment of Biology, Creighton University, Omaha, NE, 68178, USA.
Allie BrayDepartment of Mathematics, Creighton University, Omaha, NE, 68178, USA.
Andrew WaltherDepartment of Physics, Creighton University, Omaha, NE, 68178, USA.
Chisom NwakamaDepartment of Chemistry, Creighton University, Omaha, NE, 68178, USA.
Joe BamesbergerHCB Pre-health Science, Creighton University, Omaha, NE, 68178, USA.
Honour DjamDepartment of Physics, Creighton University, Omaha, NE, 68178, USA.
Kaamil AbidDepartment of Biology, Creighton University, Omaha, NE, 68178, USA.
Andrew EkpenyongDepartment of Physics, Creighton University, Omaha, NE, 68178, USA.
Creighton University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although radiotherapy and most cancer drugs target the proliferation of cancer cells, it is metastasis, the complex process by which cancer cells spread from the primary tumor to other tissues and organs of the body where they form new tumors, that leads to over 90% of all cancer deaths. Thus, there is an urgent need for anti-metastasis strategies alongside chemotherapy and radiotherapy. An important step in the metastatic cascade is migration. It is the first step in metastasis via local invasion. Here we address the question whether ionizing radiation and/or chemotherapy might inadvertently promote metastasis and/or invasiveness by enhancing cell migration. We used a standard laboratory irradiator, Faxitron CellRad, to irradiate both non-cancer (HCN2 neurons) and cancer cells (T98G glioblastoma) with 2 Gy, 10 Gy and 20 Gy of X-rays. Paclitaxel (5 μM) was used for chemotherapy. We then measured the attachment and migration of the cells using an electric cell substrate impedance sensing device. Both the irradiated HCN2 cells and T98G cells showed significantly (p < 0.01) enhanced migration compared to non-irradiated cells, within the first 20-40 h following irradiation with 20 Gy. Our results suggest that cell migration should be a therapeutic target in anti-metastasis/anti-invasion strategies for improved radiotherapy and chemotherapy outcomes.

Indexed as

Brain cancerBrain metastasisChemotherapyGlioblastomaMigrationNeuronal cellsRadioresistanceRadiosensitivityRadiotherapy

Identifiers

PMID34286111
PMCPMC8280507
OpenAlexW3186763243

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.