Evidence map›Paper›PMID 34287306›Full record

ReviewJournal of developmental biology2021

There and Back Again: Hox Clusters Use Both DNA Strands.

Elena L Novikova, Milana A Kulakova

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Toward a cell-type-specific lung HOX code.Frontiers in cell and developmental biology · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Special Issue "Hox Genes in Development: New Paradigms".Journal of developmental biology · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Elena L NovikovaDepartment of Embryology, St. Petersburg State University, Universitetskaya nab. 7-9, 199034 Saint Petersburg, Russia.
Milana A KulakovaDepartment of Embryology, St. Petersburg State University, Universitetskaya nab. 7-9, 199034 Saint Petersburg, Russia.ORCID 0000-0001-9814-3875

Funding

Russian Science Foundation 19-14-00346.
6 · The paper itself

Abstract

Bilaterian animals operate the clusters of Hox genes through a rich repertoire of diverse mechanisms. In this review, we will summarize and analyze the accumulated data concerning long non-coding RNAs (lncRNAs) that are transcribed from sense (coding) DNA strands of Hox clusters. It was shown that antisense regulatory RNAs control the work of Hox genes in cis and trans, participate in the establishment and maintenance of the epigenetic code of Hox loci, and can even serve as a source of regulatory peptides that switch cellular energetic metabolism. Moreover, these molecules can be considered as a force that consolidates the cluster into a single whole. We will discuss the examples of antisense transcription of Hox genes in well-studied systems (cell cultures, morphogenesis of vertebrates) and bear upon some interesting examples of antisense Hox RNAs in non-model Protostomia.

Indexed as

antisense ncRNAsantisense transcriptionHox cluster evolutionHox geneslinkRNAslncRNAslong noncoding RNAsNATs

Identifiers

PMID34287306
PMCPMC8293171

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.