Evidence map›Paper›PMID 34290739›Full record

ReviewFrontiers in genetics2021

Non-human Primate Models to Investigate Mechanisms of Infection-Associated Fetal and Pediatric Injury, Teratogenesis and Stillbirth.

Miranda Li, Alyssa Brokaw, Anna M Furuta, Brahm Coler, Veronica Obregon-Perko, Ann Chahroudi, Hsuan-Yuan Wang, Sallie R Permar, Charlotte E Hotchkiss, Thaddeus G Golos and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Study Models forMicroorganisms · 2025
    Review
  11. Review
  12. Review
  13. A bioprinted model of pregnant human uterine myometrium.Frontiers in bioengineering and biotechnology · 2025
    Article
  14. Non-human primate: the new frontier model of female reproductive engineering.Frontiers in bioengineering and biotechnology · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Miranda LiDepartment of Obstetrics & Gynecology, University of Washington, Seattle, WA, United States.
Alyssa BrokawDepartment of Global Health, University of Washington, Seattle, WA, United States.
Anna M FurutaDepartment of Global Health, University of Washington, Seattle, WA, United States.
Brahm ColerElson S. Floyd College of Medicine, Washington State University, Spokane, WA, United States.
Veronica Obregon-PerkoDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.
Ann ChahroudiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.
Hsuan-Yuan WangDepartment of Pediatrics, Weill Cornell Medicine, New York, NY, United States.
Sallie R PermarDepartment of Pediatrics, Weill Cornell Medicine, New York, NY, United States.
Charlotte E HotchkissWashington National Primate Research Center, University of Washington, Seattle, WA, United States.
Thaddeus G GolosDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, United States.
Lakshmi RajagopalDepartment of Global Health, University of Washington, Seattle, WA, United States.
Kristina M Adams WaldorfDepartment of Obstetrics & Gynecology, University of Washington, Seattle, WA, United States.
University of Washington · USEmory University · USColumbia University · USCornell University · USUniversity of Gothenburg · SEUniversity of Wisconsin–Madison · USWashington State University Spokane · USWeill Cornell Medicine · US

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
WaNPRC Macaca nemestrina SPF Breeding ColonyU42OD011123 · OD · UNIVERSITY OF WASHINGTON · PI Melissa R Berg, Cindy Buckmaster · 2012 to 2026
$34.4M
Virology CoreP01AI129859 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Sallie R. Permar · 2019 to 2026
$31.0M
The origin, predictors, and immune correlates of viral rebound in orally SHIV infected infant monkeysP01AI131276 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI FOUDA AMOU OU, GENEVIEVE GINY · 2017 to 2021
$8.3M
Training a New Generation of VaccinologistsT32AI074492 · NIAID · EMORY UNIVERSITY · PI Rama Rao Amara, Benjamin A Lopman · 2009 to 2026
$6.4M
Diseases of Public Health Importance Training GrantT32AI007509 · NIAID · UNIVERSITY OF WASHINGTON · PI LUND, JENNIFER M · 1997 to 2024
$6.3M
JAK-STAT Control of Zika Virus-Induced Fetal InjuryR01AI143265 · NIAID · UNIVERSITY OF WASHINGTON · PI ADAMS WALDORF, KRISTINA M., GALE, MICHAEL · 2019 to 2023
$4.6M
Role of the hyaluronidase in GBS VirulenceR01AI133976 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI ADAMS WALDORF, KRISTINA M., RAJAGOPAL, LAKSHMI · 2017 to 2021
$4.5M
Immune Control of Group B Streptococcal PlacentalR01AI145890 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI ADAMS WALDORF, KRISTINA M., RAJAGOPAL, LAKSHMI · 2019 to 2023
$4.4M
Targeted Inhibition of Interleukin-1 beta to Prevent Preterm BirthR01HD098713 · NICHD · UNIVERSITY OF WASHINGTON · PI ADAMS WALDORF, KRISTINA M., RAJAGOPAL, LAKSHMI · 2020 to 2024
$3.8M
NIAID NIH HHS P01 AI129859NIAID NIH HHS P01 AI131276NIAID NIH HHS R01 AI033706NIAID NIH HHS R01 AI107157NIAID NIH HHS R01 AI133976NIAID NIH HHS R01 AI143265NIAID NIH HHS R01 AI145890NIAID NIH HHS R01 AI152268NIAID NIH HHS T32 AI007509NIAID NIH HHS T32 AI055396NIAID NIH HHS T32 AI074492NICHD NIH HHS R01 HD098713NIH HHS P51 OD010425NIH HHS P51 OD011106NIH HHS P51 OD011132NIH HHS U42 OD011123NINDS NIH HHS R01 NS120182
6 · The paper itself

Abstract

A wide array of pathogens has the potential to injure the fetus and induce teratogenesis, the process by which mutations in fetal somatic cells lead to congenital malformations. Rubella virus was the first infectious disease to be linked to congenital malformations due to an infection in pregnancy, which can include congenital cataracts, microcephaly, hearing impairment and congenital heart disease. Currently, human cytomegalovirus (HCMV) is the leading infectious cause of congenital malformations globally, affecting 1 in every 200 infants. However, our knowledge of teratogenic viruses and pathogens is far from complete. New emerging infectious diseases may induce teratogenesis, similar to Zika virus (ZIKV) that caused a global pandemic in 2016-2017; thousands of neonates were born with congenital microcephaly due to ZIKV exposure

Indexed as

cytomegalovirusgroup B streptococcusHIVlisterianonhuman primatepreterm birthteratogenesisZika virus

Identifiers

PMID34290739
PMCPMC8287178
OpenAlexW3184501626

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.