Evidence map›Paper›PMID 34298922›Full record

ArticleInternational journal of molecular sciences2021

Reprogramming mRNA Expression in Response to Defect in RNA Polymerase III Assembly in the Yeast

Izabela Rudzińska, Małgorzata Cieśla, Tomasz W Turowski, Alicja Armatowska, Ewa Leśniewska, Magdalena Boguta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Izabela RudzińskaLaboratory of tRNA Transcription, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106 Warsaw, Poland.
Małgorzata CieślaLaboratory of tRNA Transcription, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106 Warsaw, Poland.
Tomasz W TurowskiLaboratory of tRNA Transcription, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106 Warsaw, Poland.
Alicja ArmatowskaLaboratory of tRNA Transcription, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106 Warsaw, Poland.
Ewa LeśniewskaLaboratory of tRNA Transcription, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106 Warsaw, Poland.
Magdalena BogutaLaboratory of tRNA Transcription, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106 Warsaw, Poland.ORCID 0000-0002-1545-0691
Institute of Biochemistry and Biophysics, Polish Academy of Sciences · PL

Funding

Narodowe Centrum Nauki UMO-2017/25/B/NZ1/01889
6 · The paper itself

Abstract

The coordinated transcription of the genome is the fundamental mechanism in molecular biology. Transcription in eukaryotes is carried out by three main RNA polymerases: Pol I, II, and III. One basic problem is how a decrease in tRNA levels, by downregulating Pol III efficiency, influences the expression pattern of protein-coding genes. The purpose of this study was to determine the mRNA levels in the yeast mutant

Indexed as

DNA-Directed RNA PolymerasesDown-RegulationGene Expression Regulation, FungalHumansRNA, MessengerRNA Polymerase IIRNA Polymerase IIIRNA, TransferSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscriptional ActivationTranscription FactorsTranscription, GeneticTranscriptomeUp-RegulationDNA-Directed RNA PolymerasesRbs1 protein, S cerevisiaeRNA, MessengerRNA Polymerase IIRNA Polymerase IIIRNA, TransferRpc19p protein, S cerevisiaeSaccharomyces cerevisiae ProteinsTranscription Factorsgene expressionRNA polymeraseyeast

Identifiers

PMID34298922
PMCPMC8306304
OpenAlexW3180728601

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.