Evidence map›Paper›PMID 34299056›Full record

ArticleInternational journal of molecular sciences2021

TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Is Upregulated in Lymphocytes Stimulated with Concanavalin A.

Helga Simon-Molas, Xavier Vallvé-Martínez, Irene Caldera-Quevedo, Pere Fontova, Claudia Arnedo-Pac, Anna Vidal-Alabró, Esther Castaño, Àurea Navarro-Sabaté, Núria Lloberas, Ramon Bartrons and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. BayesianMetabolites · 2023
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Helga Simon-MolasDepartament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, C/Feixa Llarga, s/n, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
Xavier Vallvé-MartínezDepartament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, C/Feixa Llarga, s/n, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.ORCID 0000-0002-8841-9804
Irene Caldera-QuevedoMolecular Imaging Department, Beatson Institute-Cancer Research UK, Glasgow G61 1BD, UK.
Pere FontovaDepartament de Nefrologia, Hospital Universitari de Bellvitge, IDIBELL, 08907 Barcelona, Spain.ORCID 0000-0002-1352-3084
Claudia Arnedo-PacInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08036 Barcelona, Spain.ORCID 0000-0002-2037-8487
Anna Vidal-AlabróDepartament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, C/Feixa Llarga, s/n, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
Esther CastañoCentres Científics i Tecnològics, Universitat de Barcelona, 08907 Barcelona, Spain.
Àurea Navarro-SabatéDepartament d'Infermeria Fonamental i Medicoquirúrgica, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, 08907 Barcelona, Spain.
Núria LloberasDepartament de Nefrologia, Hospital Universitari de Bellvitge, IDIBELL, 08907 Barcelona, Spain.
Ramon BartronsDepartament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, C/Feixa Llarga, s/n, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
Anna ManzanoDepartament de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, C/Feixa Llarga, s/n, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
Departament de Salut · ESBellvitge University Hospital · ESCancer Research UK Scotland Institute · GBInstitute for Research in Biomedicine · ESUniversitat de Barcelona · ES

Funding

Astellas European Foundation Award (13th European Society of Transplantation)Gestió d'Ajuts Universitaris i de Recerca de la Generalitat de Catalunya FI-DGR 2015Instituto de Salud Carlos III PI17/00412ISCIII Miguel Servet CP06/00067REDinREN RD12/0021/003
6 · The paper itself

Abstract

The glycolytic modulator TP53-Inducible Glycolysis and Apoptosis Regulator (TIGAR) is overexpressed in several types of cancer and has a role in metabolic rewiring during tumor development. However, little is known about the role of this enzyme in proliferative tissues under physiological conditions. In the current work, we analysed the role of TIGAR in primary human lymphocytes stimulated with the mitotic agent Concanavalin A (ConA). We found that

Indexed as

ApoptosisApoptosis Regulatory ProteinsAutophagyConcanavalin AGene Expression RegulationGlycolysisHumansLymphocytesMitogensPentose Phosphate PathwayPhosphatidylinositol 3-KinasesPhosphoric Monoester HydrolasesProto-Oncogene Proteins c-aktSignal TransductionAKT1 protein, humanApoptosis Regulatory ProteinsConcanavalin AMitogensPhosphatidylinositol 3-KinasesPhosphoric Monoester HydrolasesProto-Oncogene Proteins c-aktTIGAR protein, humanautophagyglycolysislymphocytesPI3K/AKTPPPROSTIGAR

Identifiers

PMID34299056
PMCPMC8303789
OpenAlexW3178766445

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.