Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats.

Seong Shoon Yoon, Jaesuk Yun, Bong Hyo Lee, Hee Young Kim, Chae Ha Yang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Neuro-Plastic Mechanisms of Pain and Addiction.International journal of molecular sciences · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Seong Shoon YoonDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea.ORCID 0000-0002-8182-1024

Jaesuk YunCollege of Pharmacy and Medical Research Center, Chungbuk National University, Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungbuk 28160, Korea.

Bong Hyo LeeDepartment of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea.

Hee Young KimDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea.

Chae Ha YangDepartment of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea.

Funding

Ministry of Food and Drug Safety 20182MFDS422National Research Foundation of Korea 2018R1A5A2025272National Research Foundation of Korea (NRF) grant 2019R1I1A1A01052581

6 · The paper itself

Abstract

Acupuncture affects the central nervous system via the regulation of neurotransmitter transmission. We previously showed that Shemen (HT7) acupoint stimulation decreased cocaine-induced dopamine release in the nucleus accumbens. Here, we used the intracranial self-stimulation (ICSS) paradigm to evaluate whether HT stimulation regulates the brain reward function of rats. We found that HT stimulation triggered a rightward shift of the frequency-rate curve and elevated the ICSS thresholds. However, HT7 stimulation did not affect the threshold-lowering effects produced by cocaine. These results indicate that HT7 points only effectively regulates the ICSS thresholds of the medial forebrain bundle in drug-naïve rats.

Indexed as

RewardAcupuncture TherapyAnesthetics, LocalAnimalsCocaineElectric StimulationMaleMedial Forebrain BundleRatsRats, Sprague-DawleySelf StimulationAnesthetics, LocalCocaineacupuncturebrain reward functioncocaineintracranial self-stimulationmedial forebrain bundlerats

Identifiers

PMID34299139

DOI10.3390/ijms22147519

PMCPMC8304740

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.