Evidence map›Paper›PMID 34299157›Full record

ArticleInternational journal of molecular sciences2021

The Effect of Liposomal Curcumin as an Anti-Inflammatory Strategy on Lipopolysaccharide e from

Francesca Diomede, Luigia Fonticoli, Simone Guarnieri, Ylenia Della Rocca, Thangavelu Soundara Rajan, Antonella Fontana, Oriana Trubiani, Guya Diletta Marconi, Jacopo Pizzicannella

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  9. Therapeutic Potential of Extracellular Vesicles in Oral Inflammation.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Francesca DiomedeDepartment of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-0384-6509
Luigia FonticoliDepartment of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy.
Simone GuarnieriDepartment of Neuroscience, Imaging and Clinical Sciences, Center for Advanced Studies and Technology (CAST), University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-2916-2965
Ylenia Della RoccaDepartment of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy.
Thangavelu Soundara RajanDepartment of Biotechnology, Karpagam Academy of Higher Education, Coimbatore 641021, India.ORCID 0000-0001-8728-6176
Antonella FontanaDepartment of Pharmacy, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-5391-7520
Oriana TrubianiDepartment of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-7459-4898
Guya Diletta MarconiDepartment of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0001-7754-4653
Jacopo Pizzicannella"Ss. Annunziata" Hospital, ASL 02 Lanciano-Vasto-Chieti, 66100 Chieti, Italy.
University of Chieti-Pescara · ITKarpagam Academy of Higher Education · INOspedale SS. Annunziata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Curcumin, a yellow polyphenol extracted from the turmeric root is used as a diet supplement. It exhibits anti-inflammatory, antioxidant, and antitumor properties by modulating different intracellular mechanisms. Due to their low solubility in water, the curcumin molecules must be encapsulated into liposomes to improve the bioavailability and biomedical potential. For the periodontal tissue and systemic health, it is essential to regulate the local inflammatory response. In this study, the possible beneficial effect of liposomes loaded with curcumin (CurLIP) in neural crest-derived human periodontal ligament stem cells (hPDLSCs) and in endothelial-differentiated hPDLSCs (e-hPDLSCs) induced with an inflammatory stimulus (lipopolysaccharide obtained from

Indexed as

Anti-Inflammatory Agents, Non-SteroidalCell DifferentiationCurcuminEndothelium, VascularHumansInflammationLipopolysaccharidesLiposomesNeural CrestPeriodontal LigamentPorphyromonas gingivalisReactive Oxygen SpeciesStem CellsAnti-Inflammatory Agents, Non-SteroidalCurcuminLipopolysaccharidesLiposomesReactive Oxygen Speciescardiovascular diseasecurcuminendothelial-differentiationhuman periodontal ligament stem cellsinflammationliposomePorphyromonas gingivalisreactive oxygen species

Identifiers

PMID34299157
PMCPMC8305631
OpenAlexW3177792511

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.