Evidence map›Paper›PMID 34299935›Full record

ArticleInternational journal of environmental research and public health2021

DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk.

Mirosław Śnit, Maciej Misiołek, Wojciech Ścierski, Anna Koniewska, Grażyna Stryjewska-Makuch, Sławomir Okła, Władysław Grzeszczak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. DIAPH2 gene polymorphisms and laryngeal cancer risk in men.Journal of cancer research and clinical oncology · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mirosław ŚnitDepartment and Clinic of Internal Medicine, Diabetology and Nephrology, Medical University of Silesia, 41-800 Zabrze, Poland.
Maciej MisiołekDepartment of Otorhinolaryngology and Laryngological Oncology, Medical University of Silesia, 41-800 Zabrze, Poland.
Wojciech ŚcierskiDepartment of Otorhinolaryngology and Laryngological Oncology, Medical University of Silesia, 41-800 Zabrze, Poland.ORCID 0000-0003-3242-8047
Anna KoniewskaDepartment of Otorhinolaryngology and Laryngological Oncology, Medical University of Silesia, 41-800 Zabrze, Poland.
Grażyna Stryjewska-MakuchDepartment of Laryngology and Laryngological Oncology, Upper Silesian Medical Centre of Silesian Medical University, 40-055 Katowice, Poland.ORCID 0000-0001-7967-6887
Sławomir OkłaDepartment of Otolaryngology, Head and Neck Surgery, Holy-Cross Cancer Center, 25-734 Kielce, Poland.
Władysław GrzeszczakDepartment of Internal Medicine, Diabetology and Nephrology, Medical University of Silesia, ul. 3. Maja 13-15, 41-800 Zabrze, Poland.ORCID 0000-0003-1947-3783
Medical University of Silesia · PLHoly Cross University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk. PATIENTS AND

methodsThis study including 267 patients with histologically confirmed laryngeal cancer and 157 controls. The relationship between genetic variations DIAPH2 (rs6620138), PTPRD (rs3765142) and HIC1 (rs9901806) and the onset of laryngeal cancer were investigated. Statistical analysis to calculate the relationship between DIAPH2, PTPRD and HIC1 genes polymorphism and pathogenesis of laryngeal cancer.

resultsThe results showed that rs6620138 DIAPH2 polymorphism could increase the onset risk of laryngeal cancer. Statistically significant differences in allele distribution of rs6620138 DIAPH2 and rs9901806 HIC1 in the case and control groups subgroups.

conclusionsThis study results suggested that genetic variation of rs6620138 DIAPH2 polymorphism is related to the susceptibility to laryngeal cancer. Our results provide a basis to begin basic research on the role of DIAPH2 gene in the pathogenesis of laryngeal cancer.

Indexed as

Laryngeal NeoplasmsAllelesForminsHumansKruppel-Like Transcription FactorsPolymorphism, Single NucleotideReceptor-Like Protein Tyrosine Phosphatases, Class 2DIAPH2 protein, humanForminsHIC1 protein, humanKruppel-Like Transcription FactorsPTPRD protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 2DIAPH2laryngeal cancer riskPTPRD and HIC1 gene polymorphisms

Identifiers

PMID34299935
PMCPMC8305316
OpenAlexW3181374845

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.