Evidence map›Paper›PMID 34305220›Full record

ArticleClinical microbiology newsletter2019

Herpes Simplex Virus Disease Management and Diagnostics in the Era of High-Throughput Sequencing.

Utsav Pandey, Moriah L Szpara

Abstract read
In one paragraph

Article in Clinical microbiology newsletter, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. AmidinoquinoxalineRSC advances · 2023
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Utsav PandeyDepartment of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania.
Moriah L SzparaDepartment of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania.

Funding

Genomic analysis of HSV-1 in the niche of genital infectionR21AI130676 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI SZPARA, MORIAH · 2017 to 2018
$439k
NIAID NIH HHS R21 AI130676
6 · The paper itself

Abstract

Herpes simplex virus (HSV) serotypes 1 and 2 are among the most widespread human viruses. HSV disease has a complex phenotype, with symptoms that can range from mild lesions to encephalitis. In the clinical setting, this diversity of outcomes poses a major challenge, making timely disease diagnosis and treatment challenging. High-throughput sequencing (HTS) has been one of the breakthrough technologies in the modern era of molecular biology, and it is revolutionizing the study of pathogen biology and clinical diagnostics. Here, we review recent studies that have used HTS to answer questions related to the evolution of drug resistance, transmission and spread, virulence marker identification, and the design of better antiviral therapeutics for HSV. We also highlight practical considerations for handling computational analysis of HSV genomes and adoption of HTS as a routine diagnostic procedure in the clinical laboratories.

Identifiers

PMID34305220
PMCPMC8297585

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.