Evidence map›Paper›PMID 34307380›Full record

ArticleFrontiers in cell and developmental biology2021

LncRNA NORAD Promotes Vascular Endothelial Cell Injury and Atherosclerosis Through Suppressing

Huihua Kai, Qiyong Wu, Ruohan Yin, Xiaoqiang Tang, Haifeng Shi, Tao Wang, Ming Zhang, Changjie Pan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. ATF3 aggravates kidney fibrosis via HDAC6-dependent epigenetic reprogramming.International journal of biological sciences · 2026
    Article
  4. Review
  5. Review
  6. Emerging Roles of Long Non-Coding RNAs in Cardiovascular Diseases.Journal of cellular and molecular medicine · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Cancers · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Role of LncRNAs in the Pathogenesis of Coronary Artery Disease.Reviews in cardiovascular medicine · 2023
    Review
  17. Article
  18. Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs inflammation and injury by mediating miR-20a-5p/HDAC4 axis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Huihua KaiDepartment of Radiology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Qiyong WuDepartment of Thoracic and Cardiac Surgery, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Ruohan YinDepartment of Radiology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Xiaoqiang TangDepartment of Radiology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Haifeng ShiDepartment of Radiology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Tao WangDepartment of Radiology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Ming ZhangDepartment of Radiology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Changjie PanDepartment of Radiology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Nanjing Medical University · CNChangzhou No.2 People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary artery disease (CAD) is a major atherosclerotic cardiovascular disease and the leading cause of mortality globally. Long non-coding RNAs (lncRNAs) play crucial roles in CAD development. To date, the effect of lncRNA non-coding RNA activated by DNA damage (NORAD) on atherosclerosis in CAD remains unclear. The primary aim of this study was to investigate the effect of lncRNA NORAD on vascular endothelial cell injury and atherosclerosis. Here, ox-LDL-treated human umbilical vein endothelial cells (HUVECs) and high-fat-diet (HFD)-fed ApoE

Indexed as

atherosclerosiscoronary artery diseasehistone deacetylationlncRNA NORADvascular endothelial cell injuryVEGF

Identifiers

PMID34307380
PMCPMC8301222
OpenAlexW3178152624

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.