Evidence map›Paper›PMID 34310015›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022

Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study.

Sid O'Bryant, Melissa Petersen, James Hall, Leigh Johnson, Kristine Yaffe, Meredith Braskie, Arthur W Toga, Robert A Rissman, HABLE study team

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Prospective study on physical activity and Alzheimer's disease-related biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  14. Chronic stress, social support, and Alzheimer's blood-based biomarkers in the HABS-HD study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  17. Alzheimer's disease plasma biomarkers and physical functioning in a diverse sample of adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Sid O'BryantInstitute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Melissa PetersenInstitute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
James HallInstitute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Leigh JohnsonInstitute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Kristine YaffeDepartment of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
Meredith BraskieImaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, USC, Los Angeles, California, USA.
Arthur W TogaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Robert A RissmanDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
HABLE study team
University of North Texas Health Science Center · USImaging Center · USSan Francisco VA Medical Center · USUniversity of California, San Diego · USUniversity of North Texas · USUniversity of Southern California · US

Funding

Health and Aging Brain among Latino Elders (HABLE-AT(N)) StudyR01AG058533 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JOHNSON, LEIGH A, O'BRYANT, SID E · 2020 to 2025
$45.4M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2022
$14.1M
Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican AmericansR01AG054073 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E, TOGA, ARTHUR W · 2017 to 2021
$12.6M
NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG054073NIA NIH HHS R01 AG058533NIBIB NIH HHS P41 EB015922
6 · The paper itself

Abstract

introductionNo large-scale characterizations of neurofilament light chain (NfL) have been conducted in diverse populations.

methodsBaseline data were analyzed among n = 890 Mexican Americans and n = 813 non-Hispanic Whites from the multi-ethnic Health & Aging Brain among Latino Elders (HABLE) study. Plasma NfL was measured on the Simoa platform.

resultsIn unadjusted models, NfL was significantly associated with age (P < .001), hypertension (P  < .001), dyslipidemia (P = .02), and diabetes (P  < .001). Covarying for age and sex, NfL was associated with neurodegeneration (P  < .001) and global amyloid burden levels (P = .02) in a subset with available data. NfL levels were significantly associated with diagnostic groups (Normal Cognition [NC], mild cognitive impairment [MCI], Dementia; P  < .001); however, there was no cut-score that yielded acceptable diagnostic accuracy. NfL levels produced a sensitivity of 0.60 and specificity of 0.78 with negative predictive value of 89% for detecting amyloid positivity. DISCUSSION: Plasma NfL levels are significantly impacted by age and medical co-morbidities that are common among older adults, which complicate its utility as a diagnostic biomarker.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedAgingBiomarkersBrainHumansIndependent LivingMexican AmericansBiomarkersAlzheimer's diseasediversityHispanicMexican Americanplasma NfL

Identifiers

PMID34310015
PMCPMC9228481
OpenAlexW3185540078

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.