ArticleJournal of endocrinological investigation2022
Non-thyroidal illness syndrome and SARS-CoV-2-associated multisystem inflammatory syndrome in children.
Article in Journal of endocrinological investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Thyroid diseases are associated with coronavirus disease 2019 infection.Frontiers in endocrinology · 2022Pooled it
- Interplay Between Infectious Diseases and the Endocrine System: An Overview and Clinical Insights.Endocrinology, diabetes & metabolism · 2026Review
- Long-Term Thyroid Complications Post-COVID-19: A Systematic Review.Microorganisms · 2026Review
- Machine learning predicts non-thyroidal illness syndrome (NTIS) occurrence and mortality in sepsis patients.European journal of medical research · 2025Article
- Endocrine Disorders and COVID-19 Severity in Pediatric Populations: A Systematic Review.Cureus · 2025Review
- Thyroiditis and COVID-19: focus on pediatric age. A narrative review.Journal of endocrinological investigation · 2024Review
- The prognostic significance of insulin resistance in COVID-19: a review.Journal of diabetes and metabolic disorders · 2024Review
- Relationship between thyroid function and lipid atherogenic profile in pediatric patients with multisystem inflammatory syndrome associated with COVID-19.Frontiers in pediatrics · 2024Article
- Cell-free DNA reveals distinct pathology of multisystem inflammatory syndrome in children.The Journal of clinical investigation · 2023Article
- Endocrinological Involvement in Children and Adolescents Affected by COVID-19: A Narrative Review.Journal of clinical medicine · 2023Review
- Endocrine manifestations of COVID-19 in children: A scoping review.Best practice & research. Clinical endocrinology & metabolism · 2023Article
- The triglyceride-glucose index as an indicator of insulin resistance and cardiometabolic risk in Brazilian adolescents.Archives of endocrinology and metabolism · 2023Article
- A Literature Review on SARS-CoV-2 and Other Viruses in Thyroid Disorders: Environmental Triggers or No-Guilty Bystanders?International journal of environmental research and public health · 2023Review
- Prognostic role of euthyroid sick syndrome in MIS-C: results from a single-center observational study.Frontiers in pediatrics · 2023Article
- Are Thyroid Functions Affected in Multisystem Inflammatory Syndrome in Children?Journal of clinical research in pediatric endocrinology · 2022Article
- Is non-thyroidal illness syndrome (NTIS) a clinical predictor of COVID-19 mortality in critically ill oldest old patients?Journal of endocrinological investigation · 2022Article
- Thyroid-Stimulating Hormone Predicts Total Cholesterol and Low-Density Lipoprotein Cholesterol Reduction during the Acute Phase of COVID-19.Journal of clinical medicine · 2022Article
- Six-month multidisciplinary follow-up in multisystem inflammatory syndrome in children: An Italian single-center experience.Frontiers in pediatrics · 2022Article
- Nonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium.Journal of translational medicine · 2021Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCOVID-19 disease may result in a severe multisystem inflammatory syndrome in children (MIS-C), which in turn may alter thyroid function (TF). We assessed TF in MIS-C, evaluating its impact on disease severity.
methodsWe retrospectively considered children admitted with MIS-C to a single pediatric hospital in Milan (November 2019-January 2021). Non-thyroidal illness syndrome (NTIS) was defined as any abnormality in TF tests (FT3, FT4, TSH) in the presence of critical illness and absence of a pre-existing hormonal abnormality. We devised a disease severity score by combining severity scores for each organ involved. Glucose and lipid profiles were also considered. A principal component analysis (PCA) was performed, to characterize the mutual association patterns between TF and disease severity.
resultsOf 26 (19 M/7F) patients, median age 10.7 (IQR 5.8-13.3) years, 23 (88.4%) presented with NTIS. A low FT3 level was noted in 15/23 (65.3%), while the other subjects had varying combinations of hormone abnormalities (8/23, 34.7%). Mutually correlated variables related to organ damage and inflammation were represented in the first dimension (PC1) of the PCA. FT3, FT4 and total cholesterol were positively correlated and characterized the second axis (PC2). The third axis (PC3) was characterized by the association of triglycerides, TyG index and HDL cholesterol. TF appeared to be related to lipemic and peripheral insulin resistance profiles. A possible association between catabolic components and severity score was also noted.
conclusionsA low FT3 level is common among MIS-C. TF may be useful to define the impact of MIS-C on children's health and help delineate long term follow-up management and prognosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.