ArticleEsophagus : official journal of the Japan Esophageal Society2022
The effects of hesperidin on stricture formation in corrosive esophageal burns: an experimental study.
Article in Esophagus : official journal of the Japan Esophageal Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- The Effects of Ellagic Acid on Experimental Corrosive Esophageal Burn Injury.Current issues in molecular biology · 2024Article
- A Novel Rat Model to Simulate the Benign Esophageal Stricture Induced by Endoscopic Submucosal Dissection.Clinical and experimental gastroenterology · 2024Article
- Investigation of the histopathological level of Ki-67, caspase-3 expressions of the effects of hesperidin on wound healing in the rat esophagus.Acta cirurgica brasileira · 2023Article
- Accidental ingestion of concentrated white vinegar in Hatay children in Turkey.Arhiv za higijenu rada i toksikologiju · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIM/
backgroundEsophageal strictures in children that develop as a result of accidental ingestion of corrosive substances remain an important health problem. The purpose of this study is to determine the effects of Hesperidin, an effective bioflavonoid in the proliferative and exudative phase of inflammation, on the stricture formation in corrosive esophageal burns.
methodsExperimental esophageal burns in rats were created using a modified Gehanno and Guedon model with 20% NaOH. Rats were divided into 5 groups. In the Sham group, the distal esophagus was prepared and cannulated according to the model, but no NaOH was administrated. The esophageal burn was created with NaOH in the other groups. The burned groups were divided into two groups as untreated (T
resultsHistopathologic damage scores such as inflammation, necrosis, and fibrosis were lower in the H
conclusionsThis study is the first to use Hesperidin in preventing esophageal damage in an esophageal caustic burn model. It was shown that Hesperidin was effective in reducing macroscopic and microscopic histopathologic damage in the corrosive esophageal burn model, preventing the stricture formation, and has positive effects on nutrition in rats with an esophageal burn.
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Registered trials
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