ArticleGut microbes
Transplantation of an obesity-associated human gut microbiota to mice induces vascular dysfunction and glucose intolerance.
Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Trial
- Associations of the gut microbiome and cardiometabolic risk in adolescence: the HOME study.BMC medical genomics · 2026Article
- Metabolic syndrome and a broken heart: trust your gut or risk your heart.American journal of physiology. Heart and circulatory physiology · 2026Review
- Two Sides of a Coin: Molecular, metabolic, and Phenotypic Convergence in Pediatric Undernutrition and Obesity.Current obesity reports · 2026Review
- Gut microbiome dynamics and cardiometabolic disease progression: evidence from a secondary data analysis of pooled clinical datasets.Frontiers in microbiology · 2026Article
- Pathogenesis and intervention strategies for metabolic dysfunction-associated fatty liver disease from the perspective of the gut-microbiota-liver axis.Frontiers in immunology · 2026Review
- Hidden Hunger in Pediatric Obesity: Redefining Malnutrition Through Macronutrient Quality and Micronutrient Deficiency.Nutrients · 2025Review
- Exploring the Impact of Intermittent Fasting on Vascular Function and the Immune System: A Narrative Review and Novel Perspective.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Microvascular endothelial dysfunction in vascular senescence and disease.Frontiers in cardiovascular medicine · 2025Review
- Bacillus subtilis DE111 partially reverses endothelial dysfunction in western-diet fed mice.Beneficial microbes · 2024Article
- Prebiotic effects of commercial apple juice in high-fat diet fed rat.BMC research notes · 2024Article
- Global deletion of the immune cell transcription factor, T-bet, alters gut microbiota and insulin sensitivity in mice.Frontiers in genetics · 2024Article
- Protective effects of blueberries on vascular function: A narrative review of preclinical and clinical evidence.Nutrition research (New York, N.Y.) · 2023Review
- Gut Microbiome Transplants and Their Health Impacts across Species.Microorganisms · 2023Review
- Interplay between Phytochemicals and the Colonic Microbiota.Nutrients · 2023Review
- Current Perspectives: Obesity and Neurodegeneration - Links and Risks.Degenerative neurological and neuromuscular disease · 2023Review
- Toll-like receptor 4 deletion partially protects mice from high fat diet-induced arterial stiffness despite perturbation to the gut microbiota.Frontiers in microbiomes · 2023Article
- Review
- Gut microbiota differs in composition between adults with type 1 diabetes with or without depression and healthy control participants: a case-control study.BMC microbiology · 2022Article
- The Gut Microbiota and Vascular Aging: A State-of-the-Art and Systematic Review of the Literature.Journal of clinical medicine · 2022Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
Recent preclinical data suggest that alterations in the gut microbiota may be an important factor linking obesity to vascular dysfunction, an early sign of cardiovascular disease. The purpose of this study was to begin translation of these preclinical data by examining whether vascular phenotypes in humans are transmissible through the gut microbiota. We hypothesized that germ-free mice colonized with gut microbiota from obese individuals would display diminished vascular function compared to germ-free mice receiving microbiota from lean individuals.We transplanted fecal material from obese and lean age-and sex-matched participants with disparate vascular function to germ-free mice. Using Principle Component Analysis, the microbiota of colonized mice separated by donor group along the first principle component, accounting for between 70-93% of the total variability in the dataset. The microbiota of mice receiving transplants from lean individuals was also characterized by increased alpha diversity, as well as increased relative abundance of potentially beneficial bacteria, including
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.