Evidence map›Paper›PMID 34318702›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021

Postnatal development alters functional compartmentalization of myosin light chain kinase in ovine carotid arteries.

Dane W Sorensen, Elisha R Injeti, Luisa Mejia-Aguilar, James M Williams, William J Pearce

Open access · greenAbstract readComparative Study
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Fetal Cerebral Blood Flow (Dys)autoregulation.Diagnostics (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dane W SorensenDivision of Physiology, Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California.
Elisha R InjetiDepartment of Pharmaceutical Sciences, Cedarville University School of Pharmacy, Cedarville, Ohio.
Luisa Mejia-AguilarDivision of Physiology, Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California.
James M WilliamsDivision of Physiology, Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California.
William J PearceDivision of Physiology, Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California.ORCID 0000-0002-5331-5677
Loma Linda University · USCedarville University · US

Funding

Uterine Vascular Adaptation to Pregnancy and Chronic HypoxiaP01HD083132 · NICHD · LOMA LINDA UNIVERSITY · PI ZHANG, LUBO · 2016 to 2020
$6.3M
MATURATION OF CEREBROVASCULAR RELAXANT MECHANISMSR01HL064867 · NHLBI · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J. · 2000 to 2009
$1.8M
Cerebrovascular Myosin Light Chain Phosphorylation in Fetus, Newborn, and AdultR01NS076945 · NINDS · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J. · 2011 to 2015
$1.5M
MATURATION OF CEREBROVASCULAR CONTRACTILE MECHANISMSR01HL054120 · NHLBI · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J. · 1995 to 2005
$1.2M
Glucocorticoids and Programming of the Hypertensive Vascular PhenotypeR03HD054920 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI KHORRAM, OMID A. · 2007 to 2008
$140k
NHLBI NIH HHS R01 HL054120NHLBI NIH HHS R01 HL064867NICHD NIH HHS P01 HD083132NICHD NIH HHS R03 HD054920NINDS NIH HHS R01 NS076945
6 · The paper itself

Abstract

The rate-limiting enzyme for vascular contraction, myosin light chain kinase (MLCK), phosphorylates regulatory myosin light chain (MLC

Indexed as

Age FactorsAnimalsCalciumCalmodulinCarotid ArteriesCatalysisElectric StimulationFemaleFetusGestational AgeKineticsMyosin-Light-Chain KinaseMyosin Light ChainsPhosphorylationSheep, DomesticCalciumCalmodulinMyosin-Light-Chain KinaseMyosin Light Chainsconfocal colocalizationcontractile proteinsfetal arteriesin situ enzymologyvascular maturation

Identifiers

PMID34318702
PMCPMC8530762
OpenAlexW3183565515

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.